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Systematic functional characterization of non-coding regulatory SNPs associated with central obesity
Authors: Shan-Shan Dong, Yuan-Yuan Duan, Ren-Jie Zhu, Ying-Ying Jia, Jia-Xin Chen, Xiao-Ting Huang, Shi-Hao Tang, Ke Yu, Wei Shi, Xiao-Feng Chen, Feng Jiang, Ruo-Han Hao, Yunlong Liu, Zhongbo Liu, Yan Guo, and Tie-Lin Yang
Journal: The American Journal of Human Genetics
Doi: doi.org/10.1016/j.ajhg.2024.11.005
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Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis
Authors: Xiao-Feng Chen, Yuan-Yuan Duan, Ying-Ying Jia, Qian-Hua Dong, Wei Shi, Yan Zhang, Shan-Shan Dong, Meng Li, Zhongbo Liu, Fei Chen, Xiao-Ting Huang, Ruo-Han Hao, Dong-Li Zhu, Rui-Hua Jing, Yan Guo, Tie-Lin Yang
Journal: Cell Genom
PubMed ID: 38335956
Doi: 1016/j.xgen.2024.100501
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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
Authors: Leon Tejwani, Neal G Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M Grijalva, Eunwoo Bae, Kristen Kim , Regina T Martuscello, Harry T Orr, Huda Y Zoghbi , Hayley S McLoughlin, Laura P W Ranum, Vikram G Shakkottai, Phyllis L Faust, Siyuan Wang, David van Dijk, Janghoo Lim
Journal: Neuron
PubMed ID: 38016472
Doi: 10.1016/j.neuron.2023.10.039
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Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma
Authors: Shiqun Wang , Wei Yan, Lingkai Kong , Shuguang Zuo , Jingyi Wu, Chunxiao Zhu , Huaping Huang , Bohao He, Jie Dong, Jiwu Wei
Journal: Nat Commun .
PubMed ID: 37474548
Doi: 10.1038/s41467-023-39683-z
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Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening
Authors: Peter C DeWeirdt, Abby V McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G Doench
Journal: Nat Commun
PubMed ID: 36068235
Doi: 10.1038/s41467-022-33024-2
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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses
Authors: Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid Y N Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, Ching-Seng Ang, Sarah-Jane Dawson, Paul A Beavis, Andrew H Wei, Marian L Burr, Mark A Dawson
Journal: Cancer Cell
PubMed ID: 36179686
Doi: 10.1016/j.ccell.2022.09.007
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Genomic insights into the recent chromosome reduction of autopolyploid sugarcane Saccharum spontaneum
Authors: Qing Zhang, Yiying Qi, Haoran Pan, Haibao Tang, Gang Wang, Xiuting Hua, Yongjun Wang, Lianyu Lin, Zhen Li, Yihan Li, Fan Yu, Zehuai Yu, Yongji Huang, Tianyou Wang, Panpan Ma, Meijie Dou, Zongyi Sun, Yibin Wang, Hengbo Wang, Xingtan Zhang, Wei Yao, Yuntong Wang, Xinlong Liu, Maojun Wang, Jianping Wang, Zuhu Deng, Jingsheng Xu, Qinghui Yang, ZhongJian Liu, Baoshan Chen, Muqing Zhang, Ray Ming, Jisen Zhang
Journal: Nat Genet
PubMed ID: 35654976
Doi: 10.1038/s41588-022-01084-1
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An in-library ligation strategy and its application in CRISPR/Cas9 screening of high-order gRNA combinations
Authors: Zhike Lu, Ke Ni, Yingying Wang, Yangfan Zhou, Yini Li, Jianfeng Yan, Qingkai Song, Min Liu, Yujun Xu, Zhenxing Yu, Tiannan Guo and Lijia Ma
Journal: Nucleic Acids Res
PubMed ID: 35670669
Doi: 10.1093/nar/gkac458
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Comprehensive Target Screening and Cellular Profiling of the Cancer-Active Compound b-AP15 Indicate Abrogation of Protein Homeostasis and Organelle Dysfunction as the Primary Mechanism of Action
Authors: Johannes Gubat, Karthik Selvaraju, Linda Sjöstrand, Dhananjay Kumar Singh, Maria V Turkina, Bernhard Schmierer, Pierre Sabatier, Roman A Zubarev, Stig Linder, Pádraig D'Arcy
Journal: Front Oncol
PubMed ID: 35530310
Doi: 10.3389/fonc.2022.852980
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P2X7 receptor: the regulator of glioma tumor development and survival
Authors: Damian Matyśniak, Vira Chumak, Natalia Nowak, Artur Kukla, Lilya Lehka, Magdalena Oslislok, Paweł Pomorski
Journal: Purinergic Signal
PubMed ID: 34964926
Doi: 10.1007/s11302-021-09834-2
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