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Engineered ipilimumab variants that bind human and mouse CTLA-4
Authors: Brett Robison 1, S J Diong 1, Anusha Kumar 1, Thomas M Moon , Olin Chang , Bryant Chau , Christine Bee , Ishita Barman , Arvind Rajpal , Alan J Korman , Sean West , Pavel Strop , Peter S Lee
Journal: MAbs
PubMed ID: 39849917
Doi: 10.1080/19420862.2025.2451296
Products & Services: Combinatorial DNA Libraries   
BARD1-mediated stabilization of METTL14 promotes retinal neovascularization by m6A-modifying MXD1 mRNA on a YTHDF2-dependent manner
Authors: Xianyang Liu, Shuhao Zeng, Jiayu Meng, Qian Zhou, Fan Cao, Baorui Chu, Chao Wu, Yakun Wang, Hui Feng, Xiaorui Bi, Xinyuan Chen, Wenxian Yang, Meng Tian, Hui Yang, Ke Hu, Shengping Hou
Journal: Theranostics
Doi: 10.7150/thno.110122
Products & Services: Catalog Antibody   
Teleost GSDMEc regulates GSDMEa-mediated pyroptos
Authors: Hang Xu, Meng Wu, Yujian Wang, Yaoming Jiao, Yuan Chen, Zihao Yuan, Li Sun
Journal: J Adv Res
PubMed ID: 40210150
Doi: doi.org/10.1016/j.jare.2025.04.007
Development of a highly sensitive C1QC-targeting aptamer and its application in a modified antibody-aptamer sandwich biosensor for C1QC biomarker detection
Authors: Wenwei Wu, Lixia Qian, Jie Shen, Hongmei Li, Liang-cheng Li
Journal: Sensors and Actuators: B. Chemical
Doi: doi.org/10.1016/j.snb.2025.137828
Products & Services: Single-Stranded DNA Synthesis   
Phosphorylation dependent charge block regulate the relaxation of nuclear speckle networks
Authors: Mengjun Zhang, Zhuang Gu, Yingtian Sun, Yichen Dong, Junlin Chen, Li Shu, Suibin Ma, Jierui Guo, Yuhang Liang, Qingming Qu, Ning Fang, Chuan-Qi Zhong, Yifan Ge, Zhongwen Chen, Shaohui Huang, Xin Zhang, Bo Wang
Journal: Mol Cell
PubMed ID: 40233760
Doi: 10.1016/j.molcel.2025.03.016
Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy
Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang
Journal: Advanced Functional Materials
Doi: doi.org/10.1002/adfm.202501954
Products & Services: Recombinant Proteins   
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs
Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu
Journal: Cell Discov
PubMed ID: 11962085
Doi: 10.1038/s41421-025-00779-z
Products & Services: Catalog Peptides   
Using Regular Porous Membrane-Based Blood−Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry
Authors: Yafeng Wu,Zixuan Chen,Fengxiang Chen,Juan Su,Jianyu Han,Songqin Liu
Journal: Anal Chem
PubMed ID: 40183921
Doi: 10.1021/acs.analchem.5c00365
Products & Services: Peptide Synthesis   
Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome
Authors: Eshita Das, Linh Le, Vladyslava Sokolova, James D Orth, Soyeon Park
Journal: Nat Commun
PubMed ID: 40204796
Doi: 10.1038/s41467-025-58703-8
Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis
Authors: Yihui Li, Wenqiang Sun, Xinyun Jin, Huiwen Li, Xue Liu, Jingtao Bian, Xueping Zhu
Journal: Cell Death Discov
PubMed ID: 40188090
Doi: 10.1038/s41420-025-02443-7.
Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy
Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang
Journal: ACS Nano
PubMed ID: 40190094
Doi: 10.1021/acsnano.4c17090.
Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel
Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang
Journal: Nat Commun
PubMed ID: 40246884
Doi: /10.1038/s41467-025-59061-1
Products & Services: Gene Synthesis   
Astragalus Polysaccharides Ameliorate Diabetic Bladder Dysfunction via Normalization of Neuromuscular Conduction
Authors: Shaochan Liang, Siyuan Xu, Shenglian Ye, Lang Liang, Hongliang Li, Jiaye Liu, Yao Zhang, Feng Zou, Xiaodan Liang, Bo Tan, Hongying Cao
Journal: J Agric Food Chem
PubMed ID: 40032633
Doi: 10.1021/acs.jafc.4c11577
The structure and function of the ghrelin receptor coding for drug actions
Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho
Journal: Nat Struct Mol Biol
PubMed ID: 39833471
Doi: 39833471
Products & Services: Gene Synthesis   
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator
Authors: Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Huanhuan Zhang, Tao Wang, Wenjing Sun, Shenglong Ling, Yuanchun Liu, Jinglin Lai, Wenqin Xie, Wanchao Yin, Lei Liu, H. Eric Xu, Changlin Tian
Journal: Cell Res
PubMed ID: 40118988
Doi: doi.org/10.1038/s41422-025-01095-7
A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration
Authors: Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li
Journal: ADVANCED FUNCTIONAL MATERIALS
Doi: 10.1002/adfm.202500603
Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα
Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich
Journal: Int J Mol Sci
PubMed ID: 40243928
Doi: ijms26073178
Products & Services: Gene Synthesis   
Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer
Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu
Journal: ACS Nano
PubMed ID: 40033785
Doi: 10.1021/acsnano.4c16698
GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint
Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang
Journal: Sci Adv
PubMed ID: 40043109
Doi: doi/10.1126/sciadv.adr9395
Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy
Authors: Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang
Journal: J Am Chem Soc
PubMed ID: 40065259
Doi: 10.1021/jacs.4c18511
Products & Services: Recombinant Proteins   
Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo-painting in cucumber
Authors: Yafeng Wu,Zixuan Chen,Fengxiang Chen,Juan Su,Jianyu Han,Songqin Liu
Journal: Plant Biotechnol J
PubMed ID: 39661709
Doi: 10.1111/pbi.14546
Products & Services: Oligo pool   
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris
Journal: Mol Cell
PubMed ID: 40054443
Doi: 10.1016/j.molcel.2025.02.004
The OsIAA3-OsARF16-OsBUL1 auxin signaling module regulates grain size in rice
Authors: Fengjun Xian, Shuya Liu, Jishuai Huang, Bin Xie, Lin Zhu, Qiannan Zhang, Chen Lv, Yimeng Xu, Xinrong Zhang, Jun Hu
Journal: Plant Physiol
PubMed ID: 40156155
Doi: 10.1093/plphys/kiaf122
Products & Services: Custom DNA/RNA Oligos   
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus
Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo
Journal: Bone Res
PubMed ID: 40025004
Doi: 10.1038/s41413-024-00399-5
Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors
Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen
Journal: Cell Death Differ
PubMed ID: 39901037
Doi: 10.1038/s41418-025-01454-2
Products & Services: Peptide Synthesis   
Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy
Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma
Journal: Chemical Engineering Journal
Doi: 10.1016/j.cej.2025.160862
Products & Services: Peptide Synthesis   
EXPERT expands prime editing efficiency and range of large fragment edits
Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan
Journal: Nat Commun
PubMed ID: 39939583
Doi: 10.1038/s41467-025-56734-9
Products & Services: Gene Synthesis   
Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system
Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang
Journal: Nat Commun
PubMed ID: 39984501
Doi: 10.1038/s41467-025-57153-6
Products & Services: Gene Synthesis   
Double antibody sandwich ELISA based on rabbit monoclonal antibody targeting gD protein for the detection of bovine herpesvirus 1
Authors: Qiang Liu, Xiaoxia Niu, Lingling Jiang, Gang Zhang, Pu Wang, Sinong Zhang, Weifeng Gao, Huichen Guo, Yujiong Wang, Yong Li
Journal: Int J Biol Macromol
PubMed ID: 39929469
Doi: 10.1016/j.ijbiomac.2025.140671
Products & Services: Gene Synthesis   
DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress
Authors: Zixuan Chen , Zhaoyan Tian , Yafeng Wu , Songqin Liu
Journal: Acta Biomater
PubMed ID: 39922515
Doi: 10.1016/j.actbio.2025.02.011
PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Authors: Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M McAloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy
Journal: Proc Natl Acad Sci U S A
PubMed ID: 39964718
Doi: 10.1073/pnas.2420961122
Products & Services: Peptide Synthesis   
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
Authors: Chang Peng, Haowen Jiang, Liya Jing, Wenhua Yang, Xiaotong Guan, Hanlin Wang, Sike Yu, Yutang Cao, Min Wang, Huan Ma, Zan Lv, Hongyu Gu, Chunmei Xia, Xiaozhen Guo, Bin Sun, Aili Wang, Cen Xie, Wenbiao Wu, Luyiyi Lu, Jiayi Song, Saifei Lei, Rui Wu, Yi Zang, Erjiang Tang, Jia Li
Journal: Nat Commun
PubMed ID: 39966410
Doi: 10.1038/s41467-025-57044-w
Products & Services: Peptide Synthesis   
Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3′ UTR via HuR anchorage
Authors: Xinghuan Ma , Sujia Liu , Bangda Fan , Danni Jin , Lei Miao , Lin Liu , Shubo Du , Jiaqi Lin
Journal: Mol Ther Nucleic Acids
PubMed ID: 40125272
Doi: doi.org/10.1016/j.omtn.2025.102485
Products & Services: Gene Synthesis   
Controllable intein splicing and N-terminal cleavage at mesophilic temperatures
Authors: Taylor A McNeal, Joel Weinberger, Geraldy L S Liman, Tia M Ariagno, David W Wood, Thomas J Santangelo, Christopher W Lennon
Journal: Front Bioeng Biotechnol
PubMed ID: 39991137
Doi: 10.3389/fbioe.2025.1543573
Products & Services: Gene Synthesis   Mutagenesis Services   
Distinct immunogenicity outcomes of DNA vaccines encoding malaria transmission-blocking vaccine target antigens Pfs230D1M and Pvs230D1
Authors: Yi Cao , Maisa da Silva Araujo , Cynthia G Lorang , Najara Akira Costa Dos Santos , Abhai Tripathi , Joseph Vinetz , Nirbhay Kumar
Journal: Vaccine
PubMed ID: 39787798
Doi: 10.1016/j.vaccine.2024.126696
Products & Services: Gene Synthesis   Plasmid DNA Preparation   
Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds
Authors: Jiani Lu、Yan Tang、Hongtao Li、Xixiang Chen、Pengcheng Qin、Jianrong Xu、Weihua Li 和 Lili Chen
Journal: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Doi: doi.org/10.3390/ijms26052243
Products & Services: Plasmid DNA Preparation   
Polyamine-Depleting Hydrogen-Bond Organic Frameworks Unleash Dendritic Cell and T Cell Vigor for Targeted CRISPR/Cas-Assisted Cancer Immunotherapy
Authors: Yongchun Pan, Fei Zeng, Xiaowei Luan, Guanzhong He, Shurong Qin, Qianglan Lu, Bangshun He, Xin Han, Yujun Song
Journal: Adv Mater
PubMed ID: 39972681
Doi: 10.1002/adma.202411886
Products & Services: Recombinant Proteins   
Establishment of an indirect ELISA method for detecting bovine coronavirus antibodies based on N protein
Authors: Qiang Liu , Xiaoxia Niu , Lingling Jiang , Gang Zhang , Pu Wang , Sinong Zhang , Weifeng Gao , Huichen Guo, Yujiong Wang and Yong Li
Journal: Frontiers in Veterinary Science
Doi: 10.3389/fvets.2025.1530870
Products & Services: Plasmid DNA Preparation   
In vitro reconstitution of meiotic DNA double-strand-break formation
Authors: Xinzhe Tang , Zetao Hu , Jian Ding , Meixia Wu , Pin Guan , Yawei Song , Yue Yin , Wei Wu , Jinbiao Ma , Ying Huang , Ming-Han Tong
Journal: Nature
PubMed ID: 39972125
Doi: doi.org/10.1038/s41586-024-08551-1
Products & Services: Custom DNA/RNA Oligos   
Elastin-like polypeptide: A novel titanification biomacromolecule for green and ultrafast synthesis of biotitania nanoparticles via biomimetic mineralization
Authors: Lixi Cai, Jinlin Zheng, Lixing Liu, Guangya Zhang, Yuanqing Lin
Journal: Int J Biol Macromol
PubMed ID: 40015400
Doi: 10.1016/j.ijbiomac.2025.141449
Products & Services: Gene Synthesis   
Perturbing Organelle-Level K+/Ca2+ Homeostasis by Nanotherapeutics for Enhancing Ion-Mediated Cancer Immunotherapy
Authors: Jun-Long Liang , Qian-Xiao Huang , Qi-Wen Chen , Xiao-Kang Jin , Zi-Yi Han 1, Ping Ji , Si-Xue Cheng , Wei-Hai Chen , Xian-Zheng Zhang
Journal: Adv Mater
PubMed ID: 39955648
Doi: 10.1002/adma.202416574
Products & Services: Recombinant Proteins   
Macrophage-specific in vivo RNA editing promotes phagocytosis and antitumor immunity in mice
Authors: Yuxuan Chen , Xiaohong Chen , Yao Zhang , Meng Wang , Minqi Yang , Ruiji Wang , Xiaojie Yan , Shiyi Shao , Huhu Xin , Qida Hu , Wei Wei , Yuan Ping
Journal: Sci Transl Med
PubMed ID: 39813319
Doi: 10.1126/scitranslmed.adl5800
Products & Services: Recombinant Proteins   
Structural insights into RNA cleavage by PIWI Argonaute
Authors: Zhiqing Li , Qikui Xu , Jing Zhong , Yan Zhang , Tianxiang Zhang , Xiaoze Ying , Xiaoli Lu , Xiaoyi Li , Li Wan , Junchao Xue , Jing Huang , Ying Zhen , Zhao Zhang, Jianping Wu , En-Zhi Shen
Journal: Nature
PubMed ID: 39814893
Doi: 10.1038/s41586-024-08438-1
Products & Services: Plasmid DNA Preparation   
TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance
Authors: Aidi Gao , Chao He , Hengrui Chen , Qianlin Liu , Yin Chen , Jianying Sun , Chuanfeng Wu , Ya Pan , Sonia Rocha , Mu Wang , Jundong Zhou
Journal: Proteomics Clin Appl
PubMed ID: 39375892
Doi: 10.1002/prca.202400010
Ligand-Responsive Artificial Protein–Protein Communication for Field-Deployable Cell-Free Biosensing
Authors: Ke Wang , Siqian Liu , Shuqi Zhou , Aori Qileng , Dingyi Wang , Yingju Liu , Chunlai Chen , Chunyang Lei , Zhou Nie
Journal: Angew Chem Int Ed Engl
PubMed ID: 39558180
Doi: 10.1002/anie.202416671
Products & Services: PCR Cloning and Subcloning   
Access to Axially Chiral Biaryl Benzylamines via Ancestral Enzyme- Enabled Reductive Amination Desymmetrization
Authors: Wen-Qing, ZhengXin-Xin, ZhuZheng, ZhuTairan, YangLifen, ZhengRui, PanShenlin, WangLixin, ZhangQi, ChenJian-He, XuYongtao Xie, Yongtao Xie
Journal: ACS catalysis
Doi: 10.1021/acscatal.4c06881
Products & Services: Plasmid DNA Preparation   
A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development
Authors: Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu, Yuwen Ke
Journal: The innovation
Doi: doi.org/10.1016/j.xinn.2024.100767
Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)   
Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice
Authors: Wei Song, Zi-Ming Zhou, Le-le Zhang, Hai-Feng Shu, Jin-Ru Xia, Xia Qin, Rong Hua, Yong-Mei Zhang
Journal: Cell Death Dis
PubMed ID: 39809747
Doi: 10.1038/s41419-025-07333-5
Products & Services: Peptide Synthesis   
Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation
Authors: Bing Peng , Qingyi Wang , Feixiang Zhang , Hui Shen , Peng Du
Journal: Cell Stem Cell
PubMed ID: 39826539
Doi: doi.org/10.1016/j.stem.2024.12.006

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