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Systematic functional characterization of non-coding regulatory SNPs associated with central obesity

Authors: Shan-Shan Dong, Yuan-Yuan Duan, Ren-Jie Zhu, Ying-Ying Jia, Jia-Xin Chen, Xiao-Ting Huang, Shi-Hao Tang, Ke Yu, Wei Shi, Xiao-Feng Chen, Feng Jiang, Ruo-Han Hao, Yunlong Liu, Zhongbo Liu, Yan Guo, and Tie-Lin Yang

Journal: The American Journal of Human Genetics

Doi: doi.org/10.1016/j.ajhg.2024.11.005

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Mismatch prime editing gRNA increased efficiency and reduced indels

Authors: Jidong Fei , Dongdong Zhao , Caiyi Pang , Ju Li , Siwei Li , Wentao Qiao , Juan Tan , Changhao Bi , Xueli Zhang

Journal: Nat Commun

PubMed ID: 39747083

Doi: 10.1038/s41467-024-55578-z

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Salivary elicitor disulffde isomerase from Nilaparvata lugens targets host rice UDP-glucose epimerase 2 to induce plant defenses

Authors: Jianmei Fu , Zhichang Zhao , Jichao Fang , Rui Ji

Journal: Plant Stress

Doi: doi.org/10.1016/j.stress.2025.100744

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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Authors: Yongliang Tong , Runqiu Chen , Xinrong Lu , Cuiying Chen , Guiqin Sun , Xiaolu Yu , Shaoxian Lyu , Meiqing Feng , Yiru Long , Likun Gong , Li Chen

Journal: Int J Biol Macromol

PubMed ID: 39824395

Doi: 10.1016/j.ijbiomac.2025.139953

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Restoring tumor antigenicity activates the “bystander” T cell immune cycle

Authors: Yifan Yang , Qiumin Yu , Haoyu Zhang , Yuchen Liu , Hexuan Wang , Ningyi Yang , Yulian Shi , Wanli Zhang , Zijie Wu , Shitong Huang , Wenbin Xie , Ran Duan , Qiuli Mao , Xupeiyao Shi , Zheng Gao , Xiaoning Wang , Hanlin Guo , Lingxiao Chen , Yi Han , Ximing Li , Liyuan Chen , Siqi Tang , Ying Fan , Wenbing Yao , Hong Tian , Xiangdong Gao

Journal: J Control Release

PubMed ID: 39894265

Doi: 10.1016/j.jconrel.2025.01.094

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Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells

Authors: Peng Yin , Chunzheng Huang , Li Zhang , Zhenzhen Li , Caijun Zhong , Shi Kuang , Chunyang Lei , Yan Huang , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39801450

Doi: 10.1002/anie.202424060

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Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy

Authors: Nailin Yang , Shumin Sun , Jiachen Xu , Fei Gong, Huali Lei , Yu Hao , Zifan Pei , Chenya Wang , Qiao Yu , Jihu Nie , Nan Jiang , Caifang Ni , Liang Cheng

Journal: Adv Mater

PubMed ID: 10.1002/adma.202414929

Doi: 10.1002/adma.202414929

Products & Services: Proteins, Expression, Isolation and Analysis

Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

Authors: Joan A Chick, Nadege N Abongdia, Robert A Shey, Tobias O Apinjoh

Journal: Heliyon

PubMed ID: 39906795

Doi: 10.1016/j.heliyon.2025.e42014

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An Insect Eﬀector Mimics Its Host Immune Regulator to Undermine Plant Immunity

Authors: Jianmei Fu , Shuai Li , Jing Li , Zhichang Zhao , Jing Li , Xinyang Tan , Shan Yu , Maofeng Jing , Keyan Zhu-Salzman , Jichao Fang , Rui Ji

Journal: Adv Sci (Weinh)

PubMed ID: 39853648

Doi: doi.org/10.1002/advs.202409186

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Direct repeat region 3’ end modifications regulate Cas12a activity and expand its applications

Authors: Wei Zhang , Yinyin Zhong , Jiaqi Wang , Guangrong Zou , Qiaozhen Chen , Chaoxing Liu

Journal: Nucleic Acids Res

PubMed ID: 39883010

Doi: 10.1093/nar/gkaf040

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Dictating the spatial-temporal delivery of molecular adjuvant and antigen for the enhanced vaccination

Authors: Yumeng Yan , Xiaonan Huang , Lili Yuan , To Ngai , Guanghui Ma , Yufei Xia

Journal: Biomaterials

PubMed ID: 38968687

Doi: 10.1016/j.biomaterials.2024.122697

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Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1+ Macrophages for Infectious Bone Defect Regeneration

Authors: Hao Wu , Changcheng Chen , Jiangfeng Li , Dongmei Yu , Xun Wu , Hai Huang , Zhen Tang , Qi Wu , Shichao Yan , Ning Wang , Mo Wang , Feilong Wei , Yunlong Yu , Duan Wang , Mengting Shi , Xusong Yue , Pengfei Cao , Zenghui Zheng , Xiaokang Li , Baolin Guo , Lei Shi , Zheng Guo

Journal: ACS Nano

PubMed ID: 39690461

Doi: 10.1021/acsnano.4c13562

Products & Services: Proteins, Expression, Isolation and Analysis

Remotely Sequential Activation of Biofunctional MXenes for Spatiotemporally Controlled Photothermal Cancer Therapy Integrated with Multimodal Imaging

Authors: Jing Jia , Xiaobo Zhang , Yiran Li , Tian Wang , Ying An , Xinrong Yan , Bin Liu , Chaoyi Yang , Huangxian Ju

Journal: Small

PubMed ID: 39665387

Doi: 10.1002/smll.202410535

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High-Speed Sequential DNA Computing Using a Solid-State DNA Origami Register

Authors: Qian Zhang, Mingqiang Li, Yuqing Tang, Jinyan Zhang, Chenyun Sun, Yaya Hao, Jianing Cheng, Xiaodong Xie, Sisi Jia, Hui Lv, Fei Wang, and Chunhai Fan

Journal: ACS Central Science

Doi: doi.org/10.1021/acscentsci.4c01557

Products & Services: Single-Stranded DNA Synthesis

Exploring bifunctional molecules for anti-SARS-CoV-2 and anti-inflammatory activity through structure-based virtual screening, SAR investigation, and biological evaluation

Authors: Jiani Lu , Yingying He , Yaqi Li , Xixiang Chen , Hongtao Li , Xuwen Chen , Jianrong Xu , Hongzhuan Chen ，Ying Wang , Xiao He , Shunying Liu , Lili Chen

Journal: Int J Biol Macromol

PubMed ID: 39653224

Doi: 10.1016/j.ijbiomac.2024.138529

Products & Services: Peptide Synthesis

Immunoaffinity Intact Top-Down Mass Spectrometry for Quantification of Neuron-Specific Enolase Gamma, a Low-Abundance Protein Biomarker

Authors: Sebastian A H van den Wildenberg , Sylvia A A M Genet , Maarten A C Broeren , Joost L J van Dongen , Maxime C M van den Oetelaar , Luc Brunsveld , Volkher Scharnhorst , Daan van de Kerkhof

Journal: Anal Chem

PubMed ID: 39710932

Doi: 10.1021/acs.analchem.4c04677

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Mechanistic study of SCOOPs recognition by MIK2–BAK1 complex reveals the role of N-glycans in plant ligand–receptor– coreceptor complex formation

Authors: Huimin Wu , Lihao Wan , Zunyong Liu , Yunqing Jian , Chenchen Zhang , Xiakun Mao , Zhiyun Wang , Qiang Wang , Yaxin Hu , Lizhong Xiong , Zhujun Xia , Juan Xue , Shan Li , Ping He , Libo Shan , Shutong Xu

Journal: Nat Plants

PubMed ID: 39511418

Doi: 10.1038/s41477-024-01836-3

Products & Services: Peptide Synthesis

Utilization of Fc-specific peptide to orientally immobilize antibodies markedly improves the analytical performance of lateral flow immunoassay strips for aflatoxin B1

Authors: Jin Li , Xintong Li , Yulian Wang , Qianxu Zhou , Guoqing Shi

Journal: MICROCHEMICAL JOURNAL

Doi: 10.1016/j.microc.2024.112404

Products & Services: Peptide Synthesis

SARS-CoV-2 specific adaptations in N protein inhibit NF-κB activation and alter pathogenesis

Authors: Xiao Guo , Shimin Yang , Zeng Cai , Shunhua Zhu , Hongyun Wang , Qianyun Liu , Zhen Zhang , Jiangpeng Feng , Xianying Chen , Yingjian Li , Jikai Deng , Jiejie Liu , Jiali Li , Xue Tan , Zhiying Fu , Ke Xu , Li Zhou , Yu Chen

Journal: J Cell Biol

PubMed ID: 39680116

Doi: 10.1083/jcb.202404131

Products & Services: Proteins, Expression, Isolation and Analysis

Respiratory syncytial virus glycoprotein G impedes CX3CR1-activation by CX3CL1 and monocyte function

Authors: Robert Meineke, Ayse Agac, Marie-Christin Knittler, Martin Ludlow, Albert D. M. E. Osterhaus & Guus F. Rimmelzwaan

Journal: npj viruses

Doi: doi.org/10.1038/s44298-024-00075-9

Products & Services: Gene Synthesis Mutagenesis Services

An Oral Nanovaccine Secreted by Genetically Engineered and Ultrasound-Responsive Bacteria for Colon Cancer Immunotherapy

Authors: Jiexin Li, Ruiqi Yang, Yihang Yuan, He Ren, Chao Fang, Jonathan F Lovell, and Yumiao Zhang

Journal: ADV FUNCT MATER

Doi: 10.1002/adfm.202414994

Products & Services: Peptide Synthesis Recombinant Proteins

SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β

Authors: Chun Liu , Kun Wu , Chuwen Li , Zhen Zhang , Peisong Zhai , Haiyan Guo , Jianjun Zhang

Journal: J Exp Clin Cancer Res

PubMed ID: 39726047

Doi: 10.1186/s13046-024-03255-w

Products & Services: Proteins, Expression, Isolation and Analysis

Dual-Targeted Protein MRI Contrast Agent for Early

Authors: Ruofan Hu, Zhiyang Wang, Tinghui Shen, Qianwen Yang, Weizhi Chen, Xiqun Jiang

Journal: Aggregate

Doi: 10.1002/agt2.732

Products & Services: Proteins, Expression, Isolation and Analysis

An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction

Authors: Wenzhuo Fang , Ying Wang , Kaile Zhang , Ming Yang , Meng Liu , Yangwang Jin , Xianjie Xiu , Yuhui Wang , Zhenwei Yu , Ranxing Yang , Qiang Fu

Journal: Adv Sci (Weinh)

PubMed ID: 39691071

Doi: 10.1002/advs.202409930

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Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2

Authors: Jiuyin Xu , Youwei Xu , Li Hou , Xinheng He , Yang Li , Jing Zhao , Xue Meng , James Jiqi Wang , Yanli Wu , Heng Zhang , Yunhai Li , Wen Hu , Qingning Yuan , Kai Wu , Xi Cheng , Yi Jiang , Yu Xia , H Eric Xu , Canrong Wu

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 39665758

Doi: 10.1073/pnas.2403304121

Products & Services: Proteins, Expression, Isolation and Analysis

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

Authors: Matthew J O'Neill, Chai-Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo, Rizwan Ullah, Qianyi Shen, Chek-Ying Tan, Krystian Kozek, Loren R Vanags, Devyn W Mitchell, Alex Shen, Yuko Wada, Asami Kashiwa, Lia Crotti, Federica Dagradi, Giulia Musu, Carla Spazzolini, Raquel Neves, J Martijn Bos, John R Giudicessi, Xavier Bledsoe, Eric R Gamazon, Megan C Lancaster, Andrew M Glazer, Bjorn C Knollmann, Dan M Roden, Jochen Weile, Frederick Roth, Joe-Elie Salem, Nikki Earle, Rachael Stiles, Taylor Agee, Christopher N Johnson, Minoru Horie, Jonathan R Skinner, Michael J Ackerman, Peter J Schwartz, Seiko Ohno, Jamie I Vandenberg, Brett M Kroncke

Journal: Circulation

PubMed ID: 39315434

Doi: 10.1161/CIRCULATIONAHA.124.069828

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Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses.

Authors: Tyler M. Renner, Matthew Stuible, Brian Cass, Sylvie Perret, Julie Guimond, Simon Lord-Dufour, Michael J. McCluskie, Yves Durocher & Bassel Akache

Journal: npj Viruses

Doi: 10.1038/s44298-024-00067-9

Products & Services: Gene Synthesis

Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products

Authors: Zhengren Xu, Tao Wang, Jiasheng Zou, Kaibiao Wang, Yuanning Liu, Shouqi Zhang, Yao Kong

Journal: Angew Chem Int Ed Engl

PubMed ID: 39601390

Doi: 10.1002/anie.202419092

Products & Services: Gene Synthesis

An intracellular bacterial pathogen triggers RIG-I/ MDA5-dependent necroptosis

Authors: Hang Xu , Huili Li , Boguang Sun,, Li Sun

Journal: Current Research in Microbial Sciences

Doi: doi.org/10.1016/j.crmicr.2024.100318

Products & Services: Proteins, Expression, Isolation and Analysis

Tuning the Sensitivity of MoS2 Nanopores: From Labeling to Labeling-Free Detection of DNA Methylation

Authors: Chunxiao Zhao, Yibo Yang, Pinlong Zhao, Chongbin Shi, Tianhui Tan, Hongzhen Bai, Jiandong Feng

Journal: Small Methods

PubMed ID: 39555656

Doi: 10.1002/smtd.202401532

Products & Services: Gene Synthesis Bacterial Expression

Expression and functional study of DNA polymerases from Psychrobacillus sp. BL-248-WT-3 and FJAT-21963

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Microbiol

PubMed ID: 39633807

Doi: doi.org/10.3389/fmicb.2024.1501020

Products & Services: Gene Synthesis

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning“Method for Mechanistic Investigations of Terpene Cyclases

Authors: Shouqi Zhang, Kaibiao Wang,Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan, and Zhengren Xu

Journal: ACS catalysis

Doi: 10.1021/acscatal.4c05811

Products & Services: Gene Synthesis

Bivalent CD47 immunotoxin for targeted therapy of T-cell acute lymphoblastic leukemia

Authors: Jihong Ma , Zhaohui Wang , Danielle Mintzlaff , Huiping Zhang , Rashmi Ramakrishna , Eduardo Davila , Matthew T Witkowski , M Scott Lucia , Marc S Schwartz , Elizabeth A Pomfret , David W Mathes , Zhirui Wang

Journal: Blood

PubMed ID: 39561285

Doi: 10.1182/blood.2024025277

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Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis

Authors: Ren-Yi Su, Chen-Hao Xu, Hai-Jun Guo, Li-Jun Meng, Jian-Yong Zhuo, Nan Xu, Hui-Gang Li, Chi-Yu He, Xuan-Yu Zhang, Zheng-Xin Lian, Shuai Wang, Chenhao Cao, Ruhong Zhou, Di Lu, Shu-Sen Zheng, Xu-Yong Wei, Xiao Xu

Journal: J Adv Res

PubMed ID: 39547439

Doi: 10.1016/j.jare.2024.11.021

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation

Authors: Deyu Zhang , Bo Li , Henan Xu , Jingying Li , Chao Ma , Wei Ge , Congcong Lu , and Xuetao Cao

Journal: Proc Natl Acad Sci U S A

PubMed ID: 39570315

Doi: 10.1073/pnas.2406961121

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Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis

Authors: Qimeng Liu , Tianliang Ma , Zheyu Zhang , Jiangyu Nan , Guanzhi Liu , Yute Yang , Yihe Hu , Jie Xie

Journal: J Extracell Vesicles

PubMed ID: 39711510

Doi: 10.1002/jev2.70028

Products & Services: Proteins, Expression, Isolation and Analysis

Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies

Authors: Shuhong Li , Licai Shi , Lijun Zhao , Qiaoru Guo , Jun Li , Ze-Lin Liu , Zhi Guo , Yu J Cao

Journal: Nat Commun

PubMed ID: 39528513

Doi: 10.1038/s41467-024-54150-z

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The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

Authors: Guohao Wang , Shixiao Peng , Miriam Reyes Mendez , Angelo Keramidas , David Castellano , Kunwei Wu , Wenyan Han , Qingjun Tian , Lijin Dong , Yan Li , Wei Lu

Journal: Cell

PubMed ID: 39357522

Doi: 10.1016/j.cell.2024.09.006

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Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction

Authors: Xin-Xin Zhu, Wen-Qing Zheng, Zi-Wei Xia, Xin-Ru Chen, Tian Jin, Xu-Wei Ding, Fei-Fei Chen, Qi Chen, Jian-He Xu, Xu-Dong Kong, Gao-Wei Zheng

Journal: Nat Commun

PubMed ID: 39609402

Doi: 10.1038/s41467-024-54613-3

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Interactions established by isoform-specific TrkB-T1 sequences govern inflammatory response and neurotoxicity in stroke

Authors: Lola Ugalde-Triviño, Gonzalo S. Tejeda, Gema M. Esteban-Ortega, Margarita Díaz-Guerra

Journal: bioRxiv

Doi: doi.org/10.1101/2024.11.13.623346

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RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA

Authors: Liying Zhang, Zhiheng Deng, Yunxiang Du, Ziyu Xu, Tianyi Zhang, Zebin Tong, Huasong Ai, Lu-Jun Liang, Lei Liu

Journal: Bioorg Med Chem

PubMed ID: 39580855

Doi: 10.1016/j.bmc.2024.118016

Products & Services: Gene Synthesis Proteins, Expression, Isolation and Analysis

A high-performance protein preparation approach in a single column-free step

Authors: Yuan Huang, Yuanyuan Zhang, Xiaofeng Yang, Zhanglin Lin

Journal: Trends Biotechnol

PubMed ID: 39537535

Doi: 10.1016/j.tibtech.2024.10.008

Products & Services: Proteins, Expression, Isolation and Analysis

Both chebulagic acid and punicalagin inhibit respiratory syncytial virus entry via multi-targeting glycoprotein and fusion protein

Authors: Yingcai Xiong , Keyu Tao , Tao Li , Yinghui Zhou , Zhaowei Zhang , Weiying Ou , Zhao Wang , Shouchuan Wang , Yayi Hou , Peng Cao , Jianjian Ji

Journal: J Virol

PubMed ID: 39508604

Doi: 10.1128/jvi.01536-24

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Engineered mRNAs with stable structures minimize double-stranded RNA formation and increase protein expression

Authors: Qianshan Qin , Huayuan Yan , Weixiang Gao , Ruyin Cao , Guopeng Liu , Xiaojing Zhang , Niangang Wang , Wenjie Zuo , Lei Yuan , Peng Gao , Qi Liu

Journal: J Mol Biol

PubMed ID: 39427983

Doi: 10.1016/J.JMB.2024.168822

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Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

Authors: Jing Wang , Zhengyang An , Zhongsheng Wu , Wei Zhou , Pengyu Sun , Piyu Wu , Song Dang , Rui Xue , Xue Bai , Yongtao Du , Rongmei Chen , Wenxu Wang , Pei Huang , Sin Man Lam , Youwei Ai , Suling Liu , Guanghou Shui , Zhe Zhang , Zheng Liu , Jianyong Huang , Xiaohong Fang , Kangmin He

Journal: Mol Cell

PubMed ID: 39488211

Doi: 10.1016/j.molcel.2024.10.010

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Zinc–Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy

Authors: Youdong Chen 1, Yujie Lu , Huali Lei 1, Lin Liu , Xianmin Li 1, Yuqi Yang 1, Shumin Sun 1, Qiao Yu 1, Li Wang 1, Jie Wu 1 2, Jingrui Li 1, Guanghui Hou 1, Liang Cheng

Journal: ACS Nano

PubMed ID: 39404652

Doi: 10.1021/acsnano.4c10378

Products & Services: Proteins, Expression, Isolation and Analysis

Self-Adjuvanting Bacteria Hydrogel for SHP1 Checkpoint Inhibition in Tumor-Draining Lymph Nodes to Enhance Cancer Immunotherapy

Authors: Xiuhua Pan, Feiyang Liu, Ruixin Kang, Zongwei Hu, Yueru Pang, Ziqi Shen, Xiawei Zhou, Jun Zhang, Qi Shen

Journal: ADVANCED FUNCTIONAL MATERIALS

Doi: 10.1002/adfm.202409736

Products & Services: Common Tools

SARS-CoV-2 N protein coordinates viral particle assembly through multiple domains

Authors: Yuewen Han 1, Haiwu Zhou 1, Cong Liu 1, Weiwei Wang 1, Yali Qin 2, Mingzhou Chen

Journal: Journal of Virology

PubMed ID: 39412257

Doi: 10.1128/jvi.01036-24

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Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Containing Cyclic Guanosine Monophosphate-Adenosine Monophosphate Eliminate Established Tumors

Authors: Jinchao Yu , Xinyan Li , Junyao Li , Nan Sun , Peng Cheng , Jiayi Huang , Sai Li , Rui Kuai

Journal: ACS Nano

PubMed ID: 39418110

Doi: 10.1021/acsnano.4c10673

Products & Services: Recombinant Proteins

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control

Authors: Yingwei Ge , Lijie Zhou, Yesheng Fu , Lijuan He, Yi Chen , Dingchang Li , Yuping Xie , Jun Yang , Haitao Wu, Hongmiao Dai , Zhiqiang Peng , Yong Zhang , Shaoqiong Yi , Bo Wu 1, Xin Zhang, Yangjun Zhang , Wantao Ying 1, Chun-Ping Cui , Cui Hua Liu , Lingqiang Zhang

Journal: Nature Cell Biology

PubMed ID: 39482354

Doi: 10.1038/s41556-024-01522-8

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