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Protective effects of small heat shock proteins in Daphnia magna against heavy metal exposure

Authors: Muyi Li, Ting Tang, Fengyu Yuan, Yuming Zhang, Fengchao Li, Fengsong Liu

Journal: Sci Total Environ

PubMed ID: 35907523

Doi: 10.1016/j.scitotenv.2022.157565

Products & Services: Proteins, Expression, Isolation and Analysis

Development and applications of a TaqMan based quantitative real-time PCR for the rapid detection of Pigeon circovirus (PiCV)

Authors: Babu K Nath, Shubhagata Das, Tridip Das, Jade K Forwood, Shane R Raidal

Journal: J Virol Methods

PubMed ID: 35870671

Doi: 10.1016/j.jviromet.2022.114588

Products & Services: Proteins, Expression, Isolation and Analysis

The role of hepatic Surf4 in lipoprotein metabolism and the development of atherosclerosis in apoE mice

Authors: Yishi Shen, Hong-Mei Gu, Lei Zhai, Binxiang Wang, Shucun Qin, Da-Wei Zhang

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 35803528

Doi: 10.1016/j.bbalip.2022.159196

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Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters

Authors: Charles Joussain, Olivier Le Coz, Andrey Pichugin, Peggy Marconi, Filip Lim, Mariaconcetta Sicurella, Keith Foster, François Giuliano, Alberto L Epstein, Alejandro Aranda Muñoz

Journal: Int J Mol Sci

PubMed ID: 35955608

Doi: 10.3390/ijms23158474

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Evidence for the Chemical Mechanism of RibB (3,4-Dihydroxy-2-butanone 4-phosphate Synthase) of Riboflavin Biosynthesis

Authors: Nikola Kenjić, Kathleen M Meneely, Daniel J Wherritt, Melissa C Denler, Timothy A Jackson, Graham R Moran, Audrey L Lamb

Journal: J Am Chem Soc

PubMed ID: 35802469

Doi: 10.1021/jacs.2c03376

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Impacts of a Zwitterionic Peptide on its Fusion Protein

Authors: Patrick McMullen, Liang Fang, Qi Qiao, Qing Shao, Shaoyi Jiang

Journal: Bioconjug Chem

PubMed ID: 35852436

Doi: 10.1021/acs.bioconjchem.2c00176

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Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in patients with SLE and rheumatoid arthritis

Authors: Theerada Assawasaksakul, Seelwan Sathitratanacheewin, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Yingyos Avihingsanon, Nawaporn Assawasaksakul, Wonngarm Kittanamongkolchai

Journal: Lupus Sci Med

PubMed ID: 35902168

Doi: 10.1136/lupus-2022-000726

HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway

Authors: Jing Li, Shanshan Gao

Journal: Exp Ther Med

PubMed ID: 35949323

Doi: 10.3892/etm.2022.11522

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The Relative Positioning of B and T Cell Epitopes Drives Immunodominance

Authors: Riccardo Biavasco, Marco De Giovanni

Journal: Vaccines (Basel)

PubMed ID: 36016115

Doi: 10.3390/vaccines10081227

Products & Services: Mammalian Expression

Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

Authors: Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G Zacharias, Thomas P Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj

Journal: Mol Cell

PubMed ID: 35868311

Doi: 10.1016/j.molcel.2022.06.026

Products & Services: Mammalian Expression

A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk

Journal: Cells

PubMed ID: 35883584

Doi: 10.3390/cells11142141

Products & Services: Plasmid DNA Preparation

ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria

Authors: Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie

Journal: Microorganisms

PubMed ID: 36013953

Doi: 10.3390/microorganisms10081535

Products & Services: Proteins, Expression, Isolation and Analysis

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Authors: Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang

Journal: Exp Mol Med

PubMed ID: 35879346

Doi: 10.1038/s12276-022-00806-z

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Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

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Comprehensive Evaluation and Comparison of Machine Learning Methods in QSAR Modeling of Antioxidant Tripeptides

Authors: Zhenjiao Du, Donghai Wang, Yonghui Li

Journal: ACS Omega

PubMed ID: 35910147

Doi: 10.1021/acsomega.2c03062

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Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Authors: Jean Mukherjee, Celinia A Ondeck, Jacqueline M Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H Erasmus, Patrick M McNutt, Charles B Shoemaker

Journal: Sci Rep

PubMed ID: 35803998

Doi: 10.1038/s41598-022-15876-2

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Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

Authors: Marlen Kruse, Basma Altattan, Eva-Maria Laux, Nico Grasse, Lars Heinig, Christin Möser, David M Smith, Ralph Hölzel

Journal: Sci Rep

PubMed ID: 35896714

Doi: 10.1038/s41598-022-16914-9

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HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

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Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis

Authors: Zachary Armstrong, Richard W Meek, Liang Wu, James N Blaza, Gideon J Davies

Journal: Structure

PubMed ID: 35907402

Doi: 10.1016/j.str.2022.07.001

Products & Services: Mutant Libraries

Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

Products & Services: Recombinant Proteins

Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1

Authors: Jiumei Cai, Xiaoping Wang, Wei Liao, Yiming Zhong, Lingling Chen, Zhiwei Zhang

Journal: Biomed Res Int

PubMed ID: 35845941

Doi: 10.1155/2022/1138709

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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Authors: Yong-Gang Chang, Christopher J Lupton, Charles Bayly-Jones, Alastair C Keen, Laura D'Andrea, Christina M Lucato, Joel R Steele, Hari Venugopal, Ralf B Schittenhelm, James C Whisstock, Michelle L Halls, Andrew M Ellisdon

Journal: Nat Struct Mol Biol

PubMed ID: 35864164

Doi: 10.1038/s41594-022-00804-9

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Diminished T-cell immune responses to SARS-CoV-2 omicron variant after BNT162b2 vaccination

Authors: Stanley C Jordan, Bong-Ha Shin, Edgar Rodriguez, Ashley Vo, Ruan Zhang

Journal: Immunol Lett

PubMed ID: 35843362

Doi: 10.1016/j.imlet.2022.07.004

Products & Services: Catalog Antibody

Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters

Authors: Rik L de Swart, Olav S de Leeuw, Nadia Oreshkova, Nora M Gerhards, Irina C Albulescu, Sandra Vreman, José L Gonzales, Riks Maas, Frank J M van Kuppeveld, Peter Soema, Berend-Jan Bosch, Ben P H Peeters

Journal: Vaccine

PubMed ID: 35820941

Doi: 10.1016/j.vaccine.2022.07.005

Products & Services: Mammalian Expression

Large-scale application of free energy perturbation calculations for antibody design

Authors: Fangqiang Zhu, Feliza A Bourguet, William F D Bennett, Edmond Y Lau, Kathryn T Arrildt, Brent W Segelke, Adam T Zemla, Thomas A Desautels, Daniel M Faissol

Journal: Sci Rep

PubMed ID: 35864134

Doi: 10.1038/s41598-022-14443-z

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Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Nongnaphat Yostrerat, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Jonathan Avaro, Leonard Krupnik, Antonia Neels, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard

Journal: Pharmaceutics

PubMed ID: 35890321

Doi: 10.3390/pharmaceutics14071427

Products & Services: Mammalian Expression

From functional genomics of vero cells to CRISPR-based genomic deletion for improved viral production rates

Authors: Marie-Angélique Sène, Yu Xia, Amine A Kamen

Journal: Biotechnol Bioeng

PubMed ID: 35869699

Doi: 10.1002/bit.28190

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Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy

Authors: Poulami Sarkar, Murad Ghanim

Journal: Microbiol Spectr

PubMed ID: 35863005

Doi: 10.1128/spectrum.01577-22

Products & Services: Proteins, Expression, Isolation and Analysis

Ligand-induced transmembrane conformational coupling in monomeric EGFR

Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen

Journal: Nat Commun

PubMed ID: 35794108

Doi: 10.1038/s41467-022-31299-z

Products & Services: Mutagenesis Services

NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections

Authors: Philippe Rascle, Cyril Planchais, Béatrice Jacquelin, Marie Lazzerini, Vanessa Contreras, Caroline Passaes, Asier Saez-Cirion, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin

Journal: Commun Biol

PubMed ID: 35798936

Doi: 10.1038/s42003-022-03619-y

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Structural, functional, and immunogenicity implications of F9 gene recoding

Authors: Upendra K Katneni, Aikaterini Alexaki, Ryan C Hunt, Nobuko Hamasaki-Katagiri, Gaya K Hettiarachchi, Jacob M Kames, Joseph R McGill, David D Holcomb, John C Athey, Brian Lin, Leonid A Parunov, Tal Kafri, Qi Lu, Robert Peters, Mikhail V Ovanesov, Darón I Freedberg, Haim Bar, Anton A Komar, Zuben E Sauna, Chava Kimchi-Sarfaty

Journal: Blood Adv

PubMed ID: 35413099

Doi: 10.1182/bloodadvances.2022007094

Products & Services: Plasmid DNA Preparation

Neutralizing antibody responses against SARS-CoV-2 in patients with plasma cell disorders who are on active treatment after two doses of mRNA vaccination

Authors: Al-Ola Abdallah, Zahra Mahmoudjafari, Tahani Atieh, Nausheen Ahmed, Wei Cui, Leyla Shune, Meera Mohan, Joseph McGuirk, Cassie Remker, Margaret Foss, Ellie Karloff, Heather Fitch, Shebli Atrash

Journal: Eur J Haematol

PubMed ID: 35810359

Doi: 10.1111/ejh.13826

Highly Effective Markerless Genetic Manipulation of Using a Mutated PheS-Based Counterselectable Marker

Authors: Guangjuan Gao, Dong Wei, Gang Li, Ping Chen, Liujun Wu, Siguo Liu, Yueling Zhang

Journal: Front Microbiol

PubMed ID: 35910605

Doi: 10.3389/fmicb.2022.947821

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CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Authors: Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein

Journal: Life Sci Alliance

PubMed ID: 35794005

Doi: 10.26508/lsa.202201527

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Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Authors: Gamma Chi , Qiansheng Liang , Akshay Sridhar , John B Cowgill , Kasim Sader , Mazdak Radjainia , Pu Qian , Pablo Castro-Hartmann , Shayla Venkaya , Nanki Kaur Singh , Gavin McKinley , Alejandra Fernandez-Cid , Shubhashish M M Mukhopadhyay , Nicola A Burgess-Brown , Lucie Delemotte , Manuel Covarrubias , Katharina L Dürr

Journal: Nat Commun

PubMed ID: 35840580

Doi: 10.1038/s41467-022-29594-w

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Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines

Authors: Cong Sun , Run-Yu Yuan , Chu Xie , Jiu-Feng Sun , Xin-Yan Fang , Yi-Sha Hu , Xiao-Hui Yu, Zheng Liu , Mu-Sheng Zeng , Yin-Feng Kang

Journal: J Virol

PubMed ID: 35699445

Doi: 10.1128/jvi.00383-22

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A precise and efficient adenine base editor

Authors: Tianxiang Tu , Zongming Song , Xiaoyu Liu , Shengxing Wang , Xiaoxue He , Haitao Xi , Jiahua Wang , Tong Yan , Haoran Chen , Zhenwu Zhang , Xiujuan Lv , Jineng Lv , Xiu-Feng Huang , Junzhao Zhao , Chao-Po Lin , Caixia Gao , Jinwei Zhang , Feng Gu

Journal: Mol Ther

PubMed ID: 35821638

Doi: 10.1016/j.ymthe.2022.07.010

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Native Glucagon Amyloids Catalyze Key Metabolic Reactions

Authors: Elad Arad , Gal Yosefi , Sofiya Kolusheva , Ronit Bitton , Hanna Rapaport , Raz Jelinek

Journal: ACS Nano

PubMed ID: 35866668

Doi: 10.1021/acsnano.2c05166

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Rational development of a combined mRNA vaccine against COVID-19 and influenza

Authors: Qing Ye , Mei Wu , Chao Zhou , Xishan Lu , Baoying Huang , Ning Zhang , Hui Zhao , Hang Chi , Xiaojing Zhang , Dandan Ling , Rong-Rong Zhang , Zhuofan Li , Dan Luo , Yi-Jiao Huang , Hong-Ying Qiu , Haifeng Song , Wenjie Tan , Ke Xu , Bo Ying , Cheng-Feng Qin

Journal: npj Vaccines

PubMed ID: 35882870

Doi: 10.1038/s41541-022-00478-w

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Detection of Nipah and Hendra Viruses Using Recombinant Human Ephrin B2 Capture Virus in Immunoassays

Authors: Ming Yang , Wenjun Zhu , Thang Truong , Bradley Pickering , Shawn Babiuk , Darwyn Kobasa , Logan Banadyga

Journal: Viruses

PubMed ID: 36016279

Doi: 10.3390/v14081657

Products & Services: Proteins, Expression, Isolation and Analysis

Immune responses in Omicron SARS-CoV-2 breakthrough infection in vaccinated adults

Authors: Hassen Kared, Asia-Sophia Wolf, Amin Alirezaylavasani, Anthony Ravussin, Guri Solum, Trung The Tran, Fridtjof Lund-Johansen, John Torgils Vaage, Lise Sofie Nissen-Meyer, Unni C Nygaard, Olav Hungnes, Anna H Robertson, Lisbeth Meyer Næss, Lill Trogstad, Per Magnus, Ludvig A Munthe, Siri Mjaaland

Journal: Nat Commun

PubMed ID: 35851055

Doi: 10.1038/s41467-022-31888-y

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CC chemokine receptor 5 antagonist alleviates inflammation by regulating IFN-γ/IL-10 and STAT4/Smad3 signaling in a mouse model of autoimmune encephalomyelitis

Authors: Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Mudassar Shahid, Haneen A Al-Mazroua, Homood M As Sobeai, Abdullah F Alasmari, Mohammed M Alanazi, Abdullah S Alhamed, Abdullah A Aldossari, Sabry M Attia

Journal: Cell Immunol

PubMed ID: 35872534

Doi: 10.1016/j.cellimm.2022.104580

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Persistent Reptarenavirus and Hartmanivirus Infection in Cultured Boid Cells

Authors: Annika Lintala, Leonora Szirovicza, Anja Kipar, Udo Hetzel, Jussi Hepojoki

Journal: Microbiol Spectr

PubMed ID: 35862992

Doi: 10.1128/spectrum.01585-22

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of Dense Granule Metalloproteinase INS-16 in

Authors: Hao Cui, Rui Xu, Yu Li, Yaqiong Guo, Ziding Zhang, Lihua Xiao, Yaoyu Feng, Na Li