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Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution
Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca
Journal: Int J Biol Macromol
PubMed ID: 38287572
Doi: 10.1016/j.ijbiomac.2023.127754
Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication
Authors: Puxian Fang, Congbao Xie, Ting Pan, Ting Cheng, Wei Chen, Sijin Xia, Tong Ding, Junkang Fang, Yanrong Zhou, Liurong Fang, Dengguo Wei, Shaobo Xiao
Journal: Nucleic Acids Res
PubMed ID: 37739415
Doi: 10.1093/nar/gkad759
Histone Abundance Quantification via Flow Cytometry of Htb2-GFP Allows Easy Monitoring of Cell Cycle Perturbations in Living Yeast Cells, Comparable to Standard DNA Staining
Authors: Maria V Kulakova, Eslam S M O Ghazy, Fedor Ryabov, Yaroslav M Stanishevskiy, Michael O Agaphonov, Alexander I Alexandrov
Journal: J Fungi (Basel)
PubMed ID: 37888289
Doi: 10.3390/jof9101033
A spacer design strategy for CRISPR-Cas12f1 with single-nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens
Authors: Panqi Gao, Maoyi Yang, Yi Chen, Jun Yan, Miaomiao Han, Haijun Deng, Keli Qian, Jiandong Yang, Yaoqin Lu, Ling Zhou, Ailong Huang, Xiaosong Li, Wanyan Deng, Quanxin Long
Journal: J Med Virol
PubMed ID: 37855689
Doi: 10.1002/jmv.29189
STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1
Authors: Deli Song, Xudong Jia, Yuanzhu Gao, Tong Xiao, Jia Dan, Runling Shen, Jing Cai, Jiankai Liang, Wenbo Zhu, Jun Hu, Guangmei Yan, Qinfen Zhang, Yuan Lin
Journal: Oncogene
PubMed ID: 37864032
Doi: 10.1038/s41388-023-02872-7
Products & Services: Molecular Biology Reagents   
Improved prime editing allows for routine predictable gene editing in Physcomitrium patens
Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué
Journal: J Exp Bot
PubMed ID: 37243510
Doi: 10.1093/jxb/erad189
Products & Services: Molecular Biology Reagents   
The Functional Characteristics and Soluble Expression of Saffron CCD2
Authors: Ying Wang, Siqi Li, Ze Zhou, Lifen Sun, Jing Sun, Chuanpu Shen, Ranran Gao, Jingyuan Song, Xiangdong Pu
Journal: Int J Mol Sci
PubMed ID: 37894770
Doi: 10.3390/ijms242015090
Products & Services: Gene Synthesis   
A novel nanobody-based HER2-targeting antibody exhibits potent synergistic antitumor efficacy in trastuzumab-resistant cancer cells
Authors: Xinlin Liu, Linli Luan, Xi Liu, Dingwen Jiang, Junwen Deng, Jiazhen Xu, Yang Yuan, Jiyao Xing, Bingguan Chen, Dongming Xing, Haiming Huang
Journal: Front Immunol
PubMed ID: 37954614
Doi: 10.3389/fimmu.2023.1292839
Products & Services: Monoclonal Antibody Services   
Therapeutic effect of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells on liver injury
Authors: Liushenyan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou
Journal: Folia Histochem Cytobiol
PubMed ID: 37787035
Doi: 10.5603/fhc.95291
Products & Services: Combinatorial DNA Libraries   
Dual immunization with CdtB protein and flagellin epitope offers augmented protection against enteric fever in mice
Authors: Shania Vij, Reena Thakur, Raghwendra Pratap Singh, Rashmi Kumar, Preeti Pathania, Varsha Gupta, Chander Raman Suri, Praveen Rishi
Journal: Life Sci
PubMed ID: 37918629
Doi: 10.1016/j.lfs.2023.122216
Products & Services: Custom RNAi Services   
Varying the expression pattern of the strigolactone receptor gene results in phenotypes distinct from both wild type and knockout mutants
Authors: Revel S M Drummond, Hui Wen Lee, Zhiwei Luo, Jack F Dakin, Bart J Janssen, Kimberley C Snowden
Journal: Front Plant Sci
PubMed ID: 37900765
Doi: 10.3389/fpls.2023.1277617
Products & Services: Combinatorial DNA Libraries   
Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells
Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li
Journal: JACS Au
Doi: 10.1021/jacsau.3c00421
Products & Services: Gene Synthesis   
A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering
Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang
Journal: Nat Commun .
PubMed ID: 37794017
Doi: 10.1038/s41467-023-41973-5
Products & Services: Custom DNA/RNA Oligos   CRISPR Libraries   
Intervention of AXL in EGFR Signaling via Phosphorylation and Stabilization of MIG6 in Non-Small Cell Lung Cancer
Authors: Ya-Yu Yang, Sheng-Chieh Lin, Jong-Ding Lay, Chun-Yu Cho, Te-Hsuan Jang, Hsiu-Ying Ku, Chih-Jung Yao, Shuang-En Chuang
Journal: Int J Mol Sci
PubMed ID: 37834326
Doi: 10.3390/ijms241914879
Molecular insights into the HLA-B35 molecules' classification associated with HIV control
Authors: Christian A Lobos, Demetra Sm Chatzileontiadou, Bonin Sok, Coral-Ann Almedia, Hanim Halim, Lloyd D'Orsogna, Stephanie Gras
Journal: Immunol Cell Biol
PubMed ID: 37811811
Doi: 10.1111/imcb.12698
Products & Services: Peptide Synthesis   
VP2 residue N142 of coxsackievirus A10 is critical for the interaction with KREMEN1 receptor and neutralizing antibodies and the pathogenicity in mice
Authors: Xue Li, Zeyu Liu, Xingyu Yan, Yuan Tian, Kexin Liu, Yue Zhao, Jiang Shao, Pei Hao, Chao Zhang
Journal: PLoS Pathog
PubMed ID: 37788227
Doi: 10.1371/journal.ppat.1011662
Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization
Authors: Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse
Journal: PLoS Pathog
PubMed ID: 37903160
Doi: 10.1371/journal.ppat.1011601
One ring closer to a closure: the crystal structure of the ES hydroxymethylbilane synthase intermediate
Authors: Helene J Bustad, Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Aurora Martinez, Janne Jänis, Juha P Kallio
Journal: FEBS J
PubMed ID: 37863644
Doi: 10.1111/febs.16982
New twists of a TAIL: novel insights into the histone binding properties of a highly conserved PHD finger cluster within the MLR family of H3K4 mono-methyltransferases
Authors: Claudia B Zraly, Richard Schultz, Manuel O Diaz, Andrew K Dingwall
Journal: Nucleic Acids Res
PubMed ID: 37638761
Doi: 10.1093/nar/gkad698
Products & Services: Peptide Synthesis   
Vγ9+Vδ2+ T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes
Authors: Katrin Fischer, Michaela Bradlerova, Thomas Decker, Verena Supper
Journal: Sci Rep
PubMed ID: 37903831
Doi: 10.1038/s41598-023-45587-1
Structural and dynamical changes of the Streptococcus gordonii metalloregulatory ScaR protein induced by Mn ion binding
Authors: Katarina Radman, Zoe Jelić Matošević, Dijana Žilić, Ivo Crnolatac, Nikola Bregović, Marina Kveder, Ivo Piantanida, Pedro A Fernandes, Ivana Leščić Ašler, Branimir Bertoša
Journal: Int J Biol Macromol
PubMed ID: 37866578
Doi: 10.1016/j.ijbiomac.2023.127572
Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells
Authors: Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Meghan Spears, Rui Li, Lihua Julie Zhu, Christopher Ashwood, Karl Simin, Cholsoon Jang, Arthur M Mercurio, Albertha J M Walhout, Jessica B Spinelli, Dohoon Kim
Journal: Nature
PubMed ID: 37880368
Doi: 10.1038/s41586-023-06676-3
Products & Services: Custom Vector Construction   
A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation
Authors: Lounis Yakhou, Anaelle Azogui, Nikhil Gupta, Julien Richard Albert, Fumihito Miura, Laure Ferry, Kosuke Yamaguchi, Sarah Battault, Pierre Therizols, Frédéric Bonhomme, Elouan Bethuel, Arpita Sarkar, Maxim V C Greenberg, Paola B Arimondo, Gael Cristofari, Olivier Kirsh, Takashi Ito, Pierre-Antoine Defossez
Journal: Nucleic Acids Res
PubMed ID: 37650637
Doi: 10.1093/nar/gkad719
Products & Services: Custom DNA/RNA Oligos   
Autoreactive T cells targeting type II pneumocyte antigens in COVID-19 convalescent patients
Authors: Christa Lichtensteiger, Maximilian Koblischke, Fiamma Berner, Ann-Kristin Jochum, Tobias Sinnberg, Beatrice Balciunaite, Mette-Triin Purde, Vincent Walter, Marie-Therese Abdou, Kathrin Hofmeister, Philipp Kohler, Pietro Vernazza, Werner C Albrich, Christian R Kahlert, Alexander Zoufaly, Marianna T Traugott, Lukas Kern, Urs Pietsch, Gian-Reto Kleger, Miodrag Filipovic, Manfred Kneilling, Antonio Cozzio, Oltin Pop, David Bomze, Andreas Bergthaler, Omar Hasan Ali, Judith Aberle, Lukas Flatz
Journal: J Autoimmun
PubMed ID: 37826919
Doi: 10.1016/j.jaut.2023.103118
Products & Services: Stable Cell Lines   
A Polyvalent Adhesin-Toxoid Multiepitope-Fusion-Antigen-Induced Functional Antibodies against Five Enterotoxigenic Adhesins (CS7, CS12, CS14, CS17, and CS21) but Not Enterotoxins (LT and STa)
Authors: Siqi Li, Hyesuk Seo, Ipshita Upadhyay, Weiping Zhang
Journal: Microorganisms
PubMed ID: 37894131
Doi: 10.3390/microorganisms11102473
Products & Services: Gene Synthesis   
Discovery of Nanosota-2, -3, and -4 as super potent and broad-spectrum therapeutic nanobody candidates against COVID-19
Authors: Gang Ye, Ruangang Pan, Fan Bu, Jian Zheng, Alise Mendoza, Wei Wen, Lanying Du, Benjamin Spiller, Brian E Wadzinski, Bin Liu, Stanley Perlman, Fang Li
Journal: J Virol
PubMed ID: 37855638
Doi: 10.1128/jvi.01448-23
Adaptation of the late ISC pathway in the anaerobic mitochondrial organelles of Giardia intestinalis
Authors: Alžběta Motyčková, Luboš Voleman, Vladimíra Najdrová, Lenka Arbonová, Martin Benda, Vít Dohnálek, Natalia Janowicz, Ronald Malych, Róbert Šuťák, Thijs J G Ettema, Staffan Svärd, Courtney W Stairs, Pavel Doležal
Journal: PLoS Pathog
PubMed ID: 37792908
Doi: 10.1371/journal.ppat.1010773
A 3D-printed blood-brain barrier model with tunable topology and cell-matrix interactions
Authors: Louis S Paone , Mohammed Mehdi Benmassaoud , Aidan Curran , Sebastián L Vega , Peter A Galie
Journal: Biofabrication .
PubMed ID: 37820611
Doi: 10.1088/1758-5090/ad0260
Products & Services: Peptide Synthesis   
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection
Authors: Déborah Lécuyer, Roberta Nardacci, Désirée Tannous, Emie Gutierrez-Mateyron, Aurélia Deva Nathan, Frédéric Subra, Cristina Di Primio, Paola Quaranta, Vanessa Petit, Clémence Richetta, Ali Mostefa-Kara, Franca Del Nonno, Laura Falasca, Romain Marlin, Pauline Maisonnasse, Julia Delahousse, Juliette Pascaud, Eric Deprez, Marie Naigeon, Nathalie Chaput, Angelo Paci, Véronique Saada, David Ghez, Xavier Mariette, Mario Costa, Mauro Pistello, Awatef Allouch, Olivier Delelis, Mauro Piacentini, Roger Le Grand, Jean-Luc Perfettini
Journal: Front Immunol
PubMed ID: 37920468
Doi: 10.3389/fimmu.2023.1270081
A novel recombinant S-based subunit vaccine induces protective immunity against porcine deltacoronavirus challenge in piglets
Authors: Jizong Li, Shuqing Zhao, Baotai Zhang, Jin Huang, Qi Peng, Li Xiao, Xuesong Yuan, Rongli Guo, Jinzhu Zhou, Baochao Fan, Tao Xue, Xuejiao Zhu, Chuanmin Liu, Xing Zhu, Lili Ren, Bin Li
Journal: J Virol
PubMed ID: 37846983
Doi: 10.1128/jvi.00958-23
Diversity of rhodopsin cyclases in zoospore-forming fungi
Authors: Matthias Broser, Wayne Busse, Anika Spreen, Maila Reh, Yinth Andrea Bernal Sierra, Songhwan Hwang, Tillmann Utesch, Han Sun, Peter Hegemann
Journal: Proc Natl Acad Sci U S A
PubMed ID: 37871207
Doi: 10.1073/pnas.2310600120
Products & Services: Gene Synthesis   
Construction and functional verification of size-reduced plasmids based on TMP resistance gene
Authors: Chun-Cao Li, Rui Hu, Xiu-Min Hua, Yi-Xuan Ni, Lu Ge, Lu Zhang, Wen Yu, Ni-Xin Hao, Hui Xia, Qiang Fang, Zhi-Yong Tao
Journal: Microbiol Spectr
PubMed ID: 37905802
Doi: 10.1128/spectrum.01206-23
Products & Services: Plasmid DNA Preparation   
Sustained pigmentation causes DNA damage and invokes translesion polymerase Polκ for repair in melanocytes
Authors: Madeeha Ghazi, Shivangi Khanna, Yogaspoorthi Subramaniam, Jeyashri Rengaraju, Farina Sultan, Iti Gupta, Kanupriya Sharma, Sudhir Chandna, Rajesh S Gokhale, Vivek T Natarajan
Journal: Nucleic Acids Res
PubMed ID: 37697436
Doi: 10.1093/nar/gkad704
Products & Services: Polyclonal Antibody Services   
Structure-function relationships in ShKT domain peptides: ShKT-Ts1 from the sea anemone Telmatactis stephensoni
Authors: Karoline Sanches, Lauren M Ashwood, Abisola Ave-Maria Olushola-Siedoks, Dorothy C C Wai, Arfatur Rahman, Kashmala Shakeel, Muhammad Umair Naseem, Gyorgy Panyi, Peter J Prentis, Raymond S Norton
Journal: Proteins
PubMed ID: 37794633
Doi: 10.1002/prot.26594
Products & Services: Molecular Biology Reagents   
Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness
Authors: Shengmiao Chen, Yiran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shuyuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zhengjiang Zhu, Suwen Zhao, Gaofeng Fan
Journal: Cell Rep
PubMed ID: 37831605
Doi: 10.1016/j.celrep.2023.113246
Products & Services: Molecular Biology Reagents   
Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis
Authors: Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, Ce Dou, Shiwu Dong, Jianzhong Xu, Fei Luo, Qinyu Ma
Journal: Cell Rep Med
PubMed ID: 37852176
Doi: 10.1016/j.xcrm.2023.101228
Products & Services: Custom Vector Construction   
Inherited myogenic abilities in muscle precursor cells defined by the mitochondrial complex I-encoding protein
Authors: Norio Motohashi, Katsura Minegishi, Yoshitsugu Aoki
Journal: Cell Death Dis
PubMed ID: 37857600
Doi: 10.1038/s41419-023-06192-2
Products & Services: DNA Sequencing   
Targeting the SOX2/CDP protein complex with a peptide suppresses the malignant progression of esophageal squamous cell carcinoma
Authors: Yunyun Chen, Kun Zhang, Rui Zhang, Zhuo Wang, Liang Yang, Tingting Zhao, Shihui Zhang, Yong Lin, Hongzhou Zhao, Yongpan Liu, Yuxuan Wei, Yijian Zhou, Jiaying Zhang, Xianzong Ye, Jing Zhao, Xinxin Li, Jianwen Que, Songlin Shi, Kuancan Liu
Journal: Cell Death Discov
PubMed ID: 37891174
Doi: 10.1038/s41420-023-01693-7
Products & Services: Molecular Biology Reagents   
Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis
Authors: Wei Zhang, Zhuo Wan, Di Qu, Wenqi Sun, Liang Zhang, Yuan Liang, Lei Pan, Hua Jiang, Zichen Ye, Mengying Wei, Lijun Yuan, Guodong Yang, Faguang Jin
Journal: Bioact Mater
PubMed ID: 37965241
Doi: 10.1016/j.bioactmat.2023.09.019
Products & Services: Gene Synthesis   
miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells
Authors: Qihui Jia, Yuzhu Cao, Mengmeng Zhang, Yuxin Xing, Tian Xia, Yulong Guo, Yaxin Yue, Xin Li, Xiaojun Liu, Yanhua Zhang, Donghua Li, Zhuanjian Li, Yadong Tian, Xiangtao Kang, Hong Li
Journal: Poult Sci
PubMed ID: 37939591
Doi: 10.1016/j.psj.2023.103200
ROS-scavenging anti-inflammatory nucleic acid delivery system for targeted treatment of atherosclerosis
Authors: Zunjing Liua , Zihao Liub , Yi Shanc , Chen Xub , Bingran Yub, FuJian Xub
Journal: Nano Today
Doi: 10.1016/j.nantod.2023.102005
Products & Services: Peptide Synthesis   
Kaempferol inhibits SARS-CoV-2 invasion by impairing heptad repeats-mediated viral fusion
Authors: Junwei Gao , Can Cao , Mingfei Shi , Shihao Hong , Shijie Guo , Jing Li , Tengxiao Liang , Ping Song , Ruodan Xu , Ning Li
Journal: Phytomedicine .
PubMed ID: 37421767
Doi: 10.1016/j.phymed.2023.154942
Products & Services: Peptide Synthesis   Gene Synthesis   
An artificially split class 3 intein
Authors: Tia M Ariagno , John S Smetana , Christopher W Lennon
Journal: MicroPubl Biol .
PubMed ID: 37811346
Doi: 10.17912/micropub.biology.000977
Products & Services: Gene Synthesis   PCR Cloning and Subcloning   
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia
Authors: Gabriele Casirati, Andrea Cosentino, Adele Mucci, Mohammed Salah Mahmoud, Iratxe Ugarte Zabala, Jing Zeng, Scott B Ficarro, Denise Klatt, Christian Brendel, Alessandro Rambaldi, Jerome Ritz , Jarrod A Marto, Danilo Pellin, Daniel E Bauer, Scott A Armstrong, Pietro Genovese
Journal: Nature
PubMed ID: 37648862
Doi: 10.1038/s41586-023-06496-5
Products & Services: Combinatorial DNA Libraries   
Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients
Authors: Eunice X Tan, Wen Hui Lim, Elizabeth Thong, Jean-Marc Chavatte, Jinyan Zhang, Jonathan Lim, Jocelyn Y Jin, Daniel R X Lim, Jaclyn Y T Kang, Ansel Shao Pin Tang, Kai En Chan, Caitlyn Tan, Shi Ni Tan, Benjamin Nah, Daniel Q Huang, Lin-Fa Wang, Paul A Tambyah, Jyoti Somani, Barnaby Young, Mark D Muthiah
Journal: Transplant Direct
PubMed ID: 37745946
Doi: 10.1097/TXD.0000000000001537
Ligand-displaying cells and minicells for programmable delivery of toxic payloads via type IV secretion systems
Authors: Yang Grace Li, Kouhei Kishida, Natsumi Ogawa-Kishida, Peter J Christie
Journal: MBio
PubMed ID: 37772866
Doi: 10.1128/mbio.02143-23
Quantitative assessment of near-infrared fluorescent proteins
Authors: Hanbin Zhang, Stavrini Papadaki, Xiaoting Sun, Xinyue Wang, Mikhail Drobizhev, Luxia Yao, Michel Rehbock, Reinhard W Köster, Lianfeng Wu, Kazuhiko Namikawa, Kiryl D Piatkevich
Journal: Nat Methods
PubMed ID: 37666982
Doi: 10.1038/s41592-023-01975-z
Products & Services: Molecular Biology Reagents   
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity
Authors: Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He
Journal: Signal Transduct Target Ther
PubMed ID: 37743411
Doi: 10.1038/s41392-023-01630-1
Products & Services: Peptide Synthesis   
Characterization of nanodisc-forming peptides for membrane protein studies
Authors: Bankala Krishnarjuna, Gaurav Sharma, Sang-Choul Im, Richard Auchus, G M Anantharamaiah, Ayyalusamy Ramamoorthy
Journal: J Colloid Interface Sci
PubMed ID: 37801850
Doi: 10.1016/j.jcis.2023.09.162

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