至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis.

Tumour Biol.. 2016-07; 
Qin Y,Liao ZW,Luo JY,Wu WZ,Lu AS,Su PX,Lai BQ,Wang XX.
Products/Services Used Details Operation
Molecular Biology Tools ... TRPM7 mRNA coding region (GenBank, NM_003109) inter- ference sequence (siRNA) 5′-GCGCTTTC CTTATCCACTT- 3′ was designed with an integrated use of Promega, Invitrogen, GenScript, and Dharmaco companies' RNA interference de- sign tools. ... Get A Quote

摘要

The aim of this study was to evaluate the association of functional expression of TRPM7 with nasopharyngeal carcinoma (NPC) growth. We examined the correlation of TRPM7 expression with cell growth and proliferation, cell cycle, and apoptosis in vitro in NPC cell lines and NPC tumorigenesis in mice by conducting experiments in mice and by further analyzing the tumor volume and growth. We further explored to see whether there is any positive correlation with the TRPM7 knockdown in NPC cells with their sensitivity to radiation. We found that the functional expression of TRPM7 in nasopharyngeal carcinoma is a critical requirement for physiological processes such as cell cycle, resistance to apoptosis, and cell prol... More

关键词

Apoptosis; CNE-1 cells; Nasopharyngeal carcinoma; Prognosis; Radiotherapy; STAT3; TRPM7