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Molecular Biology Tools> | ... TRPM7 mRNA coding region (GenBank, NM_003109) inter- ference sequence (siRNA) 5′-GCGCTTTC CTTATCCACTT- 3′ was designed with an integrated use of Promega, Invitrogen, GenScript, and Dharmaco companies' RNA interference de- sign tools. ... | Get A Quote |
The aim of this study was to evaluate the association of functional expression of TRPM7 with nasopharyngeal carcinoma (NPC) growth. We examined the correlation of TRPM7 expression with cell growth and proliferation, cell cycle, and apoptosis in vitro in NPC cell lines and NPC tumorigenesis in mice by conducting experiments in mice and by further analyzing the tumor volume and growth. We further explored to see whether there is any positive correlation with the TRPM7 knockdown in NPC cells with their sensitivity to radiation. We found that the functional expression of TRPM7 in nasopharyngeal carcinoma is a critical requirement for physiological processes such as cell cycle, resistance to apoptosis, and cell prol... More