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Evaluation of the effectiveness of a bMSC and BMP-2 polymeric trilayer system in cartilage repair.

Biomed Mater.. 2017-07; 
Vayas R,Reyes R, Rodríguez-Évora M, Del Rosario C, Delgado A, Évora C.
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Catalog Products ... sterilized. BMP-2 with ED 50 of 0.68, measured by its ability to induce alkaline phosphatase production by C2C12 cells, was purchased from GenScript (Piscataway, USA). 2.2. Preparation and characterization of the system. The ... Get A Quote

摘要

In this study a poly(lactide-co-glycolide) acid (PLGA) tri-layer scaffold is proposed for cartilage repair. The trilayer system consists of a base layer formed by a tablet of PLGA microspheres, a second layer composed of a microsphere suspension placed on top of the tablet, and the third layer, which constitutes an external electrospun PLGA thin polymeric membrane. Combinations of bone morphogenetic protein-2 (BMP-2) encapsulated in the microspheres of the suspension layer, and bone marrow mesenchymal stem cells (bMSC) seeded on the electrospun membrane, are evaluated by histologic analyses and immunohistochemistry in a critical size osteochondral defect in rabbits. Five experimental groups, including a control... More

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