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Novel role for endogenous mitochondrial formylated peptide-driven formyl peptide receptor 1 signalling in acute respiratory distress syndrome.

Thorax.. 2017-10; 
Dorward DA,Lucas CD,Doherty MK,Chapman GB,Scholefield EJ,Conway Morris A,Felton JM,Kipari T,Humphries DC,Robb CT,Simpson AJ,Whitfield PD,Haslett C,Dhaliwal K,Rossi AG.
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Catalog Products ... volunteers (Lothian Research Ethics Committee (#08/S1103/38)) with cell purity routinely ≥95%.21 Cells were pretreated with the FPR1 antagonist cyclosporin H (CsH) (2.5 μM, Enzo Scientific, Exeter, UK) then stimulated with 100 nM fMIT (fMMYALF; GenScript, Hong Kong ... Get A Quote

摘要

BACKGROUND: Acute respiratory distress syndrome (ARDS) is an often fatal neutrophil-dominant lung disease. Although influenced by multiple proinflammatory mediators, identification of suitable therapeutic candidates remains elusive. We aimed to delineate the presence of mitochondrial formylated peptides in ARDS and characterise the functional importance of formyl peptide receptor 1 (FPR1) signalling in sterile lung inflammation. METHODS: Mitochondrial formylated peptides were identified in bronchoalveolar lavage fluid (BALF) and serum of patients with ARDS by liquid chromatography-tandem mass spectrometry. In vitro, human neutrophils were stimulated with mitochondrial formylated peptides and their effects ass... More

关键词

ARDS; Innate Immunity; Neutrophil Biology