抗独特型抗体

产品列表

产品应用

• 药代动力学（Pharmacokinetics，PK）研究：用于检测样本中的抗体药浓度

  金斯瑞的抗独特型抗体适用于 PK 研究中的多种应用形式。

  

  金斯瑞提供两种不同类型的用于PK研究的单克隆抗独特型抗体。分别可以检测游离药物或总药物水平。

  类型	抗原阻断型	抗原非阻断型
  示意图
  特征	互补位特异	互补位非特异
  抗原结合	抑制	非抑制
  应用	检测游离型抗体药	检测抗体药总量（游离型和结合型）

• 免疫原性（Immunogenicity）研究：用作抗药物抗体（anti-drug antibody，ADA）检测的阳性对照

  金斯瑞的抗独特型抗体适用于 ADA 研究中的多种应用形式。

  

产品性能

• 高亲和力

  BLI (Biolayer interferometry) binding affinity measurements of MonoRab™ Anti-Evolocumab Antibody (39B8), mAb, Rabbit (GenScript, A02293) to Evolocumab.Evolocumab captured on HFC (Anti-Human IgG Fc) Probes can bind MonoRab™ Anti-Evolocumab Antibody (39B8), mAb, Rabbit with a dissociation constant (KD) of less than 1 pM.

  
• 高特异性

  Specificity analysis of the detection of Ocrelizumab.
  Ocrelizumab samples at 5 concentrations were spiked with 10 μg/mL of Rituximab. The test result demonstrated that the high concentration of Rituximab did not interfere with the detection of Ocrelizumab.
  In this ELISA assay, MonoRab™ Anti-Ocrelizumab Antibody (12G10), mAb, Rabbit (GenScript, A02258) was coated at a concentration of 1 μg/mL, and MonoRab™ Anti-Ocrelizumab Antibody (15E7), mAb, Rabbit (GenScript, A02259) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL.

  

  ELISA binding of Anti-Trastuzumab Antibody (11C4), mAb, Mouse (GenScript, A02032-40) with Trastuzumab and Pertuzumab. It shows the antibody does not recognize Pertuzumab.
  Coating antigen: Pertuzumab 1 µg/ml. Trastuzumab 1 µg/ml.
  Anti-Trastuzumab Antibody (11C4), mAb, Mouse (GenScript, A02032-40) dilution start from 1,000 ng/ml.

  
• 高专属性

  MRD Analysis of the Detection of Lecanemab in Biological Matrix.
  The MRD is the minimum dilution necessary for the detection of Lecanemab in biological matrix with least interference. Serum samples from cynomolgus monkey were serially diluted to determine the MRD of this assay, and the test result suggested that MRD was as 1:10.
  In this ELISA assay, MonoRab™ Anti-Lecanemab Antibody (44G1), mAb, Rabbit (GenScript, A02270) was coated at a concentration of 1 μg/ml, and MonoRab™ Anti-Lecanemab Antibody (4F2), mAb, Rabbit (GenScript, A02271) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL.

  
• 多种应用模式

  Standard Curve of Lecanemab Sandwich ELISA by Anti-Lecanemab idiotype antibody 44G1 and 4F2.
  In this Sandwich ELISA assay, MonoRab™ Anti-Lecanemab Antibody (44G1), mAb, Rabbit (GenScript, A02270) was coated at a concentration of 1 μg/ml, and MonoRab™ Anti-Lecanemab Antibody (4F2), mAb, Rabbit (GenScript, A02271) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL. GenScript can provide customized conjugation service for this product per customer's request.
  In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square equal to 0.99971. The typicaldynamic range of the assay is 0.31 - 20 ng/mL and its detection limit is 0.31 ng/mL.

  

  Standard curve of the detection of Abatacept by Anti-Abatacept Antibody (CT.E8) and anti-human IgG Fc antibody.
  In the ELISA assay shown in this chart, Anti-Abatacept Antibody (CT.E8), mAb, Mouse (GenScript, A02263) was coated at a concentration of 1 μg/ml, and Mouse Anti-Human IgG Fc Antibody (50B4A9)[HRP], mAb (GenScript, A01854) was used as a detection antibody at a dilution of 1:2000.
  In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square is greater than 0.99. The typicaldynamic range of the assay is 4.69-300 ng/mL and its sensitivity of detecting Abatacept is up to 4.69 ng/mL.

  

  Standard curve and specificity analysis of the detection of Certolizumab pegol by Anti-Certolizumab Antibody (12A3) and anti-PEG antibody.
  In the ELISA assay shown in this chart, THE™ PEG Antibody, mAb, Mouse (GenScript, A01795) was coated at a concentration of 2 μg/mL, and MonoRab™ Anti-Certolizumab Antibody (12A3), mAb, Rabbit (GenScript, A02269) conjugated with Biotin was used as a detection antibody at a concentration of 0.5 μg/mL.In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square is greater than 0.999. The typicaldynamic range of the assay is 0.55-400 ng/mL and its sensitivity of detecting Certolizumab pegol is up to 0.55 ng/mL.

  
• 多种抗体类型

  Anti-Zolbetuximab Antibody (34E11) or (9C9) inhibits the binding of Zolbetuximab to Claudin18.2 (CLDN18.2).
  Anti-Zolbetuximab Antibody (34E11), mAb, Mouse (GenScript, A02260) exhibited non-inhibitory properties, whereas Anti-Zolbetuximab Antibody (9C9), mAb, Mouse (GenScript, A02261) demonstrated significant inhibitory properties with an IC₅₀ value of 0.44 µg/mL.

  
• 适用于ADC、双抗等不同结构类型的分析物

  Standard curve of the detection of Trastuzumab deruxtecan (DS-8201) by Anti-Trastuzumab Antibody (15H2) and DXd Antibody (39F4)
  In this ELISA assay, Anti-Trastuzumab Antibody (11C4), mAb, Mouse (GenScript, A02032) was coated at a concentration of 2 μg/mL, and DXd Antibody (39F4), mAb, Mouse (GenScript, A02217) conjugated with HRP was used as a detection antibody at a concentration of 0.22 μg/mL.
  In this assay, a four-parameter logistic curve fitting program was used to create a standard curve with the R-Square is greater than 0.99. The typicaldynamic range of the assay is 1.56 - 100 ng/mL and its sensitivity of detecting Trastuzumab deruxtecan (DS-8201) is up to 1.56 ng/mL.

  

相关资料

抗独特型抗体 抗独特型抗体

助力抗体药药代动力学和免疫原性研究

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