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Transthyretin stability is critical in assisting beta amyloid clearance–Relevance of transthyretin stabilization in Alzheimer's disease.

CNS Neurosci Ther.. 2017-07; 
Alemi M,, Silva SC,, Santana I, Cardoso I.
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Catalog Products ... Transport studies were performed by supplementing the brain side with 500 pg/mL (0.11 n mol L −1 ) Aβ1-42 (Genscript ® , Piscataway, NJ, USA), in the absence or presence of WT TTR-633 or L55P TTR-633 preincubated with or without IDIF. … Get A Quote

摘要

BACKGROUND: The absence of transthyretin (TTR) in AD mice decreases brain Aβ clearance and reduces the low-density lipoprotein receptor-related protein 1 (LRP1). It is possible that neuroprotection by TTR is dependent on its tetramer structural stability, as studies using TTR mutants showed that unstable L55P TTR has low affinity for Aβ, and TTR tetrameric stabilizers such as iododiflunisal ameliorate AD features in vivo. METHODS: We firstly investigated TTR folding status in human plasma measuring the resistance to urea denaturation. The importance of TTR stability on Aβ internalization was studied in human cerebral microvascular endothelial (hCMEC/D3) and hepatoma cells (HepG2), by flow cytometry. To inv... More

关键词

Alzheimer's disease; blood-brain barrier; liver; stability; transthyretin