至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice.

Cell Mol Gastroenterol Hepatol.. 2016-04; 
Choi KM, Gibbons SJ, Sha L, Beyder A, Verhulst PJ, Cipriani G, Phillips JE, Bauer AJ, Ordog T, Camp JJ, Ge X, Bharucha AE, Linden DR, Szurszewski JH, Kashyap PC, Farrugia G.
Products/Services Used Details Operation
Catalog Products ... After development of delayed gastric emptying, mice were assigned to treatment with vehicle or IL10 (GenScript, Piscataway, NJ or Insight Genomics, Falls Church, VA, 1 or 0.1µg intraperitoneally, twice a day). We alternated the assignment to treatment based on ... Get A Quote

摘要

Gastroparesis is a complication of diabetes characterized by delayed emptying of stomach contents and accompanied by early satiety, nausea, vomiting, and pain. No safe and reliable treatments are available. Interleukin 10 (IL10) activates the M2 cytoprotective phenotype of macrophages and induces expression of heme oxygenase 1 (HO1) protein. We investigated whether IL10 administration could improve gastric emptying and reverse the associated cellular and electrical abnormalities in diabetic mice. METHODS: Nonobese diabetic mice with delayed gastric emptying were given either IL10 (0.1-1 μg, twice/day) or vehicle (controls). Stomach tissues were isolated, and sharp microelectrode recordings were made of the ele... More

关键词

Alternatively Activated Macrophages; CO, carbon monoxide; Electrical Slow Wave; HO1, heme oxygenase 1; Heme Oxygenase 1; ICC, interstitial cells of Cajal; IL10, interleukin 10; MDA, malondialdehyde; NADPH, reduced nicotinamide adenine dinucleotide phosphate; NOD, nonobese diabetic; NOS, nitric oxide synthase; PBS, phosphate-buffered saline