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Regulation of trunk neural crest delamination by δEF1 and Sip1 in the chicken embryo.

Dev Growth Differ.. 2016-02; 
Yasumi T1, Inoue M1, Maruhashi M1, Kamachi Y1,2, Higashi Y1,3, Kondoh H1,4, Uchikawa M1.
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摘要

The vertebrate Zfhx1 transcription factor family comprises δEF1 and Sip1, which bind to CACCT-containing sequences and act as transcriptional repressors. It has been a longstanding question whether these transcription factors share the same regulatory functions in vivo. It has been shown that neural crest (NC) delamination depends on the Sip1 activity at the cranial level in mouse and chicken embryos, and it remained unclear how NC delamination is regulated at the trunk level. We observed that the expression of δEF1 and Sip1 overlaps in many tissues in chicken embryos, including NC cells at the trunk level. To clarify the above questions, we separately knocked down δEF1 and Sip1 or in combination in NC cells... More

关键词

Sox10; Zfhx1 transcription factors; chicken neural crest; shRNA-mediated knockdown