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Targeting Heat Shock Protein 70 using Gold Nanorods Enhances Cancer Cell Apoptosis in Low Dose Plasmonic Photothermal Therapy.

Biomaterials.. 2016-09; 
Ali MR, Ali HR, Rankin CR, El-Sayed MA.
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摘要

Plasmonic photothermal therapy (PPTT) is a promising cancer treatment where plasmonic nanoparticles are used to convert near infrared light to localized heat to cause cell death, mainly via apoptosis and necrosis. Modulating PPTT to induce cell apoptosis is more favorable than necrosis. Herein, we used a mild treatment condition using gold nanorods (AuNRs) to trigger apoptosis and tested how different cell lines responded to it. Three different cancer cell lines of epithelial origin: HSC (oral), MCF-7 (breast) and Huh7.5 (liver) had comparable AuNRs uptake and were heated to same environmental temperature (under 50 °C). However, Huh7.5 cells displayed a significant increase in cell apoptosis after PPTT as comp... More

关键词

Gold nanorods (AuNRs); Heat shock protein 70 (HSP70); Plasmonic photothermal therapy (PPTT); Protein refolding; Quercetin (QE)