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Targeting Btk with ibrutinib inhibit gastric carcinoma cells growth.

Am J Transl Res.. 2016-07; 
Wang JD, Chen XY, Ji KW, Tao F.
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Catalog Products ... Btk knockdown assay Btk expression in MKN-45 and BGC-823 cells was knocked down using siRNA. The Btk (Smartpool) and non-targeted RNA were obtained from GenScript (Nanjing, China). The siRNAs were transfected to cells according to the manufacturer's instruction. ... Get A Quote

摘要

Bruton's tyrosine kinase (Btk) is a member of the Tec-family non-receptor tyrosine kinases family. It has previously been reported to be expressed in B cells and has an important role in B-cell malignancies. While the roles of Btk in the pathogenesis of certain B-cell malignancies are well established, the functions of Btk in gastric carcinoma have never been investigated. Herein, we found that Btk is over-expressed in gastric carcinoma tissues and gastric cancer cells. Knockdown of Btk expression selectively inhibits the growth of gastric cancer cells, but not that of the normal gastric mucosa epithelial cell, which express very little Btk. Inhibition of Btk by its inhibitor ibrutinib has an additive inhibitor... More

关键词

Btk; Ibrutinib; gastric carcinoma