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Small-molecule fusion inhibitors bind the pH-sensing SSP-GP2 subunit interface of the Lassa virus envelope glycoprotein.

J Virol.. 2016-08; 
Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH.
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Peptide Synthesis ... containing 50 mM Tris, pH 7.5, 250 mM NaCl, 100 µM ZnCl2 and 0.1% DDM 156 (wash buffer) and LASV GPC was eluted with the addition of 5 µM 3XFLAG 157 peptide (Genscript). Following dialysis to remove the small peptide, the sample 158 Page 7. 7 ... Get A Quote

摘要

Arenavirus species are responsible for severe life-threatening hemorrhagic fevers in western Africa and South America. Without effective antiviral therapies or vaccines, these viruses pose serious public health and biodefense concerns. Chemically distinct small-molecule inhibitors of arenavirus entry have recently been identified and shown to act on the arenavirus envelope glycoprotein (GPC) to prevent membrane fusion. In the tripartite GPC complex, pH-dependent membrane fusion is triggered through a poorly understood interaction between the stable signal peptide (SSP) and the transmembrane fusion subunit GP2, and our genetic studies have suggested that these small-molecule inhibitors act at this interface to a... More

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