| Products/Services Used | Details | Operation |
|---|---|---|
| Molecular Biology Tools | ... Based on results obtained with the siRNA Target Finder (https://www.genscript.com/tools/sirna-target-finder), the target sequence of ggatcagattgacatcacc was chosen to downregulate endogenous human ADAM23 in ReNcell VM cells (ReNeuron). ... | Get A Quote |
BACKGROUND: ADAM23 is widely expressed in the embryonic central nervous system and plays an important role in tissue formation. RESULTS: In this study, we showed that ADAM23 contributes to cell survival and is involved in neuronal differentiation during the differentiation of human neural progenitor cells (hNPCs). Upregulation of ADAM23 in hNPCs was found to increase the number of neurons and the length of neurite, while its downregulation decreases them and triggers cell apoptosis. RNA microarray analysis revealed mechanistic insights into genes and pathways that may become involved in multiple cellular processes upon up- or downregulation of ADAM23. CONCLUSIONS: Our results suggest that ADAM23 regulates neuro... More
