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Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population.

Gene. 2019-03; 
ZhaoXinqian, HeJing, XieGuoyan, XuSong, XieJun, ChenYouyuan, W
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PCR and Cloning … Only DNA samples with a purity of 1.8–2.0 were included for analysis. 2.3. Polymerase chain reaction. Polymerase chain reaction was carried out by using High-Stability PCR Kit (GenScript, Nanjing, China). Each PCR was carried out in a 20 μl reaction … Get A Quote

摘要

Acute lung injury (ALI) is a serious clinical syndrome that can cause respiratory failure and threaten the life of the patients. A biomarker that can predict the syndrome can contribute to a better clinical management of the patients. In adults, genetic polymorphisms in inflammatory-response genes have been shown to be a promising biomarker. However, the pathogenesis of ALI in adult is known to be different from that in children and no previous study has investigated the association between inflammatory gene polymorphisms and pediatric ALI (PALI) risk. In this work, we examined the association between 12 polymorphisms in six inflammatory-response genes (TNF, IL6, IL10, IL18, NFKB1 and NFKBIA) and ... More

关键词

Biomarkers,Inflammation,Pediatric acute lung injury (PALI),Polymorph