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Dynamic Expression of Interferon Lambda Regulated Genes in Primary Fibroblasts and Immune Organs of the Chicken.

Genes (Basel). 2019-03; 
ArslanMehboob, YangXin, SanthakumarDiwakar, LiuXingjian, HuXiaoyuan, MunirMuhammad, LiYinü, ZhangZhi
Products/Services Used Details Operation
Gene Synthesis … XP_015144667.1], and Xenopus tropicalis (frog) [NP_001165236.1] were acquired from the National Center for Biotechnology Information (NCBI) and … chIFN-λ genes were optimized for expression in the silkworm (Bombyx mori) and synthesized by GenScript Company (China) … Get A Quote
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摘要

Interferons (IFNs) are pleiotropic cytokines that establish a first line of defense against viral infections in vertebrates. Several types of IFN have been identified; however, limited information is available in poultry, especially using live animal experimental models. IFN-lambda (IFN-λ) has recently been shown to exert a significant antiviral impact against viral pathogens in mammals. In order to investigate the in vivo potential of chicken IFN-λ (chIFN-λ) as a regulator of innate immunity, and potential antiviral therapeutics, we profiled the transcriptome of chIFN-λ-stimulated chicken immune organs (in vivo) and compared it with primary chicken embryo fibroblasts (in vitro). Employing the bacul... More

关键词

ISGs,RNA-Seq,Transcriptome,antiviral pathway,interferon la