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Influenza-induced immune suppression to methicillin-resistant Staphylococcus aureus is mediated by TLR9.

PLoS Pathog.. 2019-01; 
Martínez-ColónGiovanny J, Warheit-NiemiHelen, GurczynskiStephen J, TaylorQuincy M, WilkeCarol A, PodsiadAmy B, CrespoJoel, BhanUrvashi, MooreBetha
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Bacterial Expression System Author summary Influenza-associated secondary bacterial infections, particularly with methicillin-resistant Staphylococcus aureus (MRSA), are a major cause of morbidity and mortality, and better therapeutic strategies are needed. Stimulation of TLR2 has shown promise for …. Gene-Specific primers and probes were designedwith the GenScript Real-time PCR primer design software (Genscript Biotech Corporation Get A Quote

摘要

Bacterial lung infections, particularly with methicillin-resistant Staphylococcus aureus (MRSA), increase mortality following influenza infection, but the mechanisms remain unclear. Here we show that expression of TLR9, a microbial DNA sensor, is increased in murine lung macrophages, dendritic cells, CD8+ T cells and epithelial cells post-influenza infection. TLR9-/- mice did not show differences in handling influenza nor MRSA infection alone. However, TLR9-/- mice have improved survival and bacterial clearance in the lung post-influenza and MRSA dual infection, with no difference in viral load during dual infection. We demonstrate that TLR9 is upregulated on macrophages even when they are not... More

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