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Beneficial anti-inflammatory effects of combined rosuvastatin and cilostazol in a TNF-driven inflammatory model.

Pharmacol Rep. 2019; 
ChoOkki,JangYou-Jin,ParkKyung-Yeon,HeoTae
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PCR Cloning and Subcloning … Mouse monoclonal antibody specific for GAPDH was purchased from GenScript (Piscataway, NJ, USA). Horseradish peroxidase (HRP)-conjugated goat anti-rabbit IgG or mouse IgG were purchased from BETHYL (Montgomery, TX, USA) … Get A Quote

摘要

Due to anti-inflammatory and anti-thrombotic functions, statins and antiplatelets are widely used for patients with cardiovascular-related or coronary artery diseases. Patients with systemic or complex diseases are commonly prescribed multiple targeted medications; thus, a proper combination of two or more drugs for beneficial efficacy is considered in clinical therapy. Recent studies have suggested that combinational therapy with statins and other medications accelerates their single effect to suppress inflammatory responses. However, the therapeutic efficacy and underlying mechanism of combination treatment with rosuvastatin and cilostazol have been poorly studied.

关键词

Cilostazol,Inflammation,LPS,Rosuvastatin