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Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development.

Immunol. Cell Biol.. 2019; 
GoodallKatharine J,NguyenAngela,MatsumotoAya,McMullenJulie R,EckleSidonia B,BertolinoPatrick,SullivanLucy C,AndrewsDani
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PCR Cloning and Subcloning … further purified by size exclusion chromatography using Superdex 75 column with a buffer containing 25 mM Hepes (pH 7.4) with 150 mM NaCl. Generation of tetramers: cDNA encoding residues 20-274 of H2-Q10 and H2-T3/TL were generated by Genscript and cloned into a … Get A Quote

摘要

Class Ib major histocompatibility complex (MHC) is an extended family of molecules, which demonstrate tissue-specific expression and presentation of monomorphic antigens. These characteristics tend to imbue class Ib MHC with unique functions. H2-Q10 is potentially one such molecule that is overexpressed in the liver but its immunological function is not known. We have previously shown that H2-Q10 is a ligand for the natural killer cell receptor Ly49C and now, using H2-Q10-deficient mice, we demonstrate that H2-Q10 can also stabilize the expression of Qa-1b. In the absence of H2-Q10, the development and maturation of conventional hepatic natural killer cells is disrupted. We also provide evidence that H2... More

关键词

CD8αα,natural killer cells,non-classical MHC,γδT c