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Structural investigation of selective binding dynamics for the pheromone‐binding protein 1 of the grapevine moth, Lobesia botrana

Arch Insect Biochem Physiol. 2019-07; 
Venthur H,, Machuca J,, Godoy R,, Palma-Millanao R, Zhou JJ,, Larama G,, Bardehle L,, Quiroz A,, Ceballos R, Mutis A,,
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Bacterial Expression System To obtain recombinant LbotPBP1 for the binding assays, clones were synthesized by GenScript Get A Quote

摘要

The European grapevine moth, Lobesia botrana (Denis & Schiffermüller), is a serious pest in vineyards in North and South America. Mating disruption techniques have been used to control and monitor L. botrana on the basis of its sexual communication. This needs a well-tuned olfactory system, in which it is believed that pheromone-binding proteins (PBPs) are key players that transport pheromones in the antennae of moths. In this study, the selectivity of a PBP, named as LbotPBP1, was tested by fluorescence binding assays against 11 sex pheromone components and 6 host plant volatiles. In addition, its binding mechanism was predicted on the basis of structural analyses by molecular docking and comp... More

关键词

Tortricidae; molecular modeling; odorant-binding protein; olfactory system