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Scavenger receptor SREC-I mediated entry of TLR4 into lipid microdomains and triggered inflammatory cytokine release in RAW 264.7 cells upon LPS activation.

PLoS ONE. 2015; 
MurshidAyesha,GongJianlin,PrinceThomas,BorgesThiago J,CalderwoodStua
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Monoclonal Antibody Services … Mouse anti-human SREC-I monoclonal antibody was a gift from Dr H Adachi (Laboratory of Cellular Biochemistry, Riken, Saitama, Japan) and rabbit monoclonal mouse anti-SREC-I ab was custom synthesized by GenScript (Piscataway, NJ) against specific peptide sequence … Get A Quote

摘要

Scavenger receptor associated with endothelial cells I (SREC-I) was shown to be expressed in immune cells and to play a role in the endocytosis of peptides and antigen presentation. As our previous studies indicated that SREC-I required intact Toll-like receptor 4 (TLR4) expression for its functions in tumor immunity, we examined potential interactions between these two receptors. We have shown here that SREC-I became associated with TLR4 on binding bacterial lipopolysaccharides (LPS) in RAW 264.7 and HEK 293 cells overexpressing these two receptors. The receptors then became internalized together in intracellular endosomes. SREC-I promoted TLR4-induced signal transduction through the NF-kB and MAP kinase pat... More

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