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The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication.

Sci Signal. 2015; 
IngleHarshad,KumarSushil,RautAshwin Ashok,MishraAnamika,KulkarniDiwakar Dattatraya,KameyamaTakeshi,TakaokaAkinori,AkiraShizuo,KumarHima
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摘要

MicroRNAs (miRNAs) are small noncoding RNAs that are responsible for dynamic changes in gene expression, and some regulate innate antiviral responses. Retinoic acid-inducible gene I (RIG-I) is a cytosolic sensor of viral RNA; RIG-I activation induces an antiviral immune response. We found that miR-485 of the host was produced in response to viral infection and targeted RIG-I mRNA for degradation, which led to suppression of the antiviral response and enhanced viral replication. Thus, inhibition of the expression of mir-485 markedly reduced the replication of Newcastle disease virus (NDV) and the H5N1 strain of influenza virus in mammalian cells. Unexpectedly, miR-485 also bound to the H5N1 gene PB1 (whi... More

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