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Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.

Sci Rep. 2015; 
MukaiSatomi,YabutaNorikazu,YoshidaKaori,OkamotoAyumi,MiuraDaisaku,FurutaYasuhide,AbeTakaya,NojimaHir
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Mutant Libraries The coding regions of HsMdm2 was cloned by PCR from human myometrium cDNA libraries, and HsCdc25B was chemically synthesized (GenScript, Piscataway, NJ, USA). Get A Quote

摘要

Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by coordinating the balance between cell proliferation and apoptosis. Importantly, Lats1 and Lats2 also play pivotal roles in cell cycle checkpoint and mitosis. The Lats proteins localize at centrosomes, but their centrosomal functions remain elusive. Here, we generated Lats1-null knockout (Lats1(-/-)) mice and established Lats1-null mouse embryonic fibroblasts (MEFs). In Lats1(-/-) MEFs, centrosomes were mar... More

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