Products/Services Used | Details | Operation |
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Recombinant Antibody Services> | … Ltd. (Shanghai, China). 1,4-Butanediol digly- cidyl ether, 4-dimethylaminobenzaldehyde, and 4',6-diamidino- 2-phenylindole (DAPI) were purchased from Sigma-Aldrich (St. Louis, MO, USA). Recombinant human VEGF was purchased from GenScript Corp. (Nanjing, China) … | Get A Quote |
Bioprosthetic heart valves (BHVs) used in the clinic are mostly fixed by glutaraldehyde and the lack of endothelialization is a major problem for glutaraldehyde-fixed pericardia. Hyaluronic acid is a major glycosaminoglycan that exists in native heart valves. Coupled with its inherent biocompatibility, it may enhance endothelial adhesion and proliferation when associated with vascular endothelial growth factor (VEGF). In this study, an optimized system is developed to improve the endothelialization of glutaraldehyde-fixed pericardium. A hybrid pericardium with VEGF-loaded hyaluronic acid hydrogel coating is developed by the crosslinking of 1,4-butanediol diglycidyl ether. The adhesion and growth potential... More