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Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development.

Eur. J. Neurosci.. 2010; 
MarchettiGiovanni,EscuinSarah,van der FlierArjan,De ArcangelisAdèle,HynesRichard O,Georges-LabouesseElisa
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Common Tools a5 integrin target sequences were designed via the GenScript shRNA design tool and are as follows: Get A Quote

摘要

During cerebral cortex development, post-mitotic neurons interact with radial glial fibers and the extracellular environment to migrate away from the ventricular region and form a correct laminar structure. Integrin receptors are major mediators of cell-cell and cell-extracellular matrix interactions. Several integrin heterodimers are present during formation of the cortical layers. The alpha5beta1 receptor is expressed in the neural progenitors of the ventricular zone during cerebral cortex formation. Using in utero electroporation to introduce short hairpin RNAs in the brain at embryonic day 15.5, we were able to inhibit acutely the expression of alpha5 integrin in the developing cortex. The knockdown of ... More

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