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ZNF580 - a brake on Interleukin-6.

J Inflamm (Lond). 2018; 
StenzelPhilipp，NagorsenKaj，BerndJonathan，LeppertUlrike，ZakrzewiczAndreas，BerkholzJa
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Plasmid DNA Preparation … For transient transfection of full-length ZNF580, the human expression plasmid pcDNA3.1 + /C-(K)-DYK-ZNF580 (GenScript, USA Inc.) was used in combination with the TurboFect reagent (Thermo Scientific) according to the manufacturer's instructions. Reporter gene assay … Get A Quote

摘要

Zinc finger protein 580 (ZNF580) was reported to modulate angiogenesis， endothelial homeostasis and blood pressure control. ZNF580 regulated genes include VEGF-A and IL-8. However， it is unknown if ZNF580 could play a role during inflammation. The aim of this study was to find out if ZNF580 affects the expression of IL-6， if it occurs in monocytic cells and responds to inflammatory mediators.

关键词

Interleukin 6，LPS，Monocytes，Sepsis，ZN
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