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A novel long non-coding RNA TONSL-AS1 regulates progression of gastric cancer via activating TONSL.

Exp Cell Res. 2019-09; 
WangPeng,YangXi,ZhaoLiang,LiuDongxiao,LiuJunmao,DingYon
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PCR and Cloning … A First Strand cDNA Synthesis Kit (TakaRa, China) was used to perform reverse transcription. Primers used for real-time quantitative polymerase chain reaction (RT-qPCR) were obtained from GenScript (Nanjing, China). According … Get A Quote

摘要

Long non-coding RNAs (lncRNAs) are reported to play a significant role in various malignant tumors, yet their potential functions in gastric cancer are not clear. In this study, we found a novel lncRNA, named TONSL-AS1, was downregulated in gastric cancer tissues and cell lines compared with the normal. TONSL-AS1 inhibited cell migration, invasion and proliferation in SGC-7901, MGC-803?cells. Furthermore, TONSL-AS1 could suppress cell tumorigenesis in vivo. Mechanistically, TONSL-AS1's genomic neighboring gene TONSL, which was reported as a tumor suppress gene, was upregulated by TONSL. Additionally, the TONSL-AS1 was positively associated with TONSL in cancer tissues. Our study revealed t... More

关键词

Gastric cancer,Long non-coding RNA,TONSL,TONSL