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Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N-Glycosylation in Antibody-Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sj?gren's Syndrome.

Arthritis Rheumatol. 2018; 
Koelsch Kristi A,Cavett Joshua,Smith Kenneth,Moore Jacen S,Lehoux Sylvain D,Jia Nan,Mather Tim,Quadri Syed M S,Rasmussen Astrid,Kaufman C Erick,Lewis David M,Radfar Lida,Scordino Teresa A,Lessard Christopher J,Kurien Biji T,Cummings Richard D,James Judith A,Sivils Kathy L,Farris A Darise,Scofield R
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Nucleic Acid Purification & Analysis , samples were loaded into a 4-12% SDS-PAGE gel (GenScript) and electrophoresed prior to transfer onto Get A Quote

摘要

To better understand the role of B cells, the potential mechanisms responsible for their aberrant activation, and the production of autoantibodies in the pathogenesis of Sj?gren's syndrome (SS), this study explored patterns of selection pressure and sites of N-glycosylation acquired by somatic mutation (acN-glyc) in the IgG variable (V) regions of antibody-secreting cells (ASCs) isolated from the minor salivary glands of patients with SS and non-SS control patients with sicca symptoms.

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