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Evidence of Alternative Modes of B Cell Activation Involving Acquired Fab Regions of N-Glycosylation in Antibody-Secreting Cells Infiltrating the Labial Salivary Glands of Patients With Sj?gren's Syndrome.

Arthritis Rheumatol. 2018;

Koelsch Kristi A，Cavett Joshua，Smith Kenneth，Moore Jacen S，Lehoux Sylvain D，Jia Nan，Mather Tim，Quadri Syed M S，Rasmussen Astrid，Kaufman C Erick，Lewis David M，Radfar Lida，Scordino Teresa A，Lessard Christopher J，Kurien Biji T，Cummings Richard D，James Judith A，Sivils Kathy L，Farris A Darise，Scofield R

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Nucleic Acid Purification & Analysis	, samples were loaded into a 4-12% SDS-PAGE gel (GenScript) and electrophoresed prior to transfer onto	Get A Quote

摘要

To better understand the role of B cells， the potential mechanisms responsible for their aberrant activation， and the production of autoantibodies in the pathogenesis of Sj?gren's syndrome (SS)， this study explored patterns of selection pressure and sites of N-glycosylation acquired by somatic mutation (acN-glyc) in the IgG variable (V) regions of antibody-secreting cells (ASCs) isolated from the minor salivary glands of patients with SS and non-SS control patients with sicca symptoms.