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GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

Sci Rep. 2017; 
Lo Michael K,Jordan Robert,Arvey Aaron,Sudhamsu Jawahar,Shrivastava-Ranjan Punya,Hotard Anne L,Flint Mike,McMullan Laura K,Siegel Dustin,Clarke Michael O,Mackman Richard L,Hui Hon C,Perron Michel,Ray Adrian S,Cihlar Tomas,Nichol Stuart T,Spiropoulou Christi
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PCR and Cloning . Briefly, a bacteriophage T7 polymerase-based NiV minigenome was syn- thesized (Genscript) expressing Get A Quote

摘要

GS-5734 is a monophosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human primate model of Ebola virus infection. It has been administered under compassionate use to two Ebola patients, both of whom survived, and is currently in Phase 2 clinical development for treatment of Ebola virus disease. Here we report the antiviral activities of GS-5734 and the parent nucleoside analog across multiple virus families, providing evidence to support new indications for this compound against human viruses of significant public health concern.

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