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A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Infection in Mice.

Front Microbiol. 2018; 
Peng Zhong,Wang Shaohui,Gide Mussie,Zhu Duolong,Lamabadu Warnakulasuriya Patabendige Hiran Malinda,Li Chunhui,Cai Jianfeng,Sun Xin
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摘要

is the leading cause of worldwide antibiotics-associated diarrhea. In this study, we report the construction and evaluation of a novel bacteriophage lysin-human defensin fusion protein targeting . The fusion protein, designated LHD, is composed of two parts connected by a 3-repeating unit linker "(GGGGS)": the catalytic domain of a lysin protein from a bacteriophage phiC2 (LCD), and the functional domain of a human defensin protein HD. Lytic assays showed that LHD protein had a potent lytic activity against different types of clinical strains, including the epidemic 027, 078, 012, and 087 strains. The minimum inhibitory concentration (MIC) of LHD was 0.78 μg/ml, which was lower than the MIC... More

关键词

Clostridioides difficile infection,lysin-human defensin fusion protein,lytic activity,novel bacteriophage,treat