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A Phage Protein Aids Bacterial Symbionts in Eukaryote Immune Evasion.

Cell Host Microbe. 2019; 
Jahn Martin T,Arkhipova Ksenia,Markert Sebastian M,Stigloher Christian,Lachnit Tim,Pita Lucia,Kupczok Anne,Ribes Marta,Stengel Stephanie T,Rosenstiel Philip,Dutilh Bas E,Hentschel
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Bacterial Expression System The 568 nt ANKp encoding phage gene (BCvir 4986 ORF 10) was optimized for E. coli codon usage and then de-novo synthesized in collaboration with GenScript (Piscataway, NJ, USA). Get A Quote

摘要

Phages are increasingly recognized as important members of host-associated microbiomes, with a vast genomic diversity. The new frontier is to understand how phages may affect higher order processes, such as in the context of host-microbe interactions. Here, we use marine sponges as a model to investigate the interplay between phages, bacterial symbionts, and eukaryotic hosts. Using viral metagenomics, we find that sponges, although massively filtering seawater, harbor species-specific and even individually unique viral signatures that are taxonomically distinct from other environments. We further discover a symbiont phage-encoded ankyrin-domain-containing protein, which is widely spread in pha... More

关键词

ankyrin,community ecology,immune evasion,innate immunity,marine sponge,phage,symbiosis,viro