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The archaeal Dps nanocage targets kidney proximal tubules via glomerular filtration.

J. Clin. Invest.. 2019; 
UchidaMasaki,MaierBernhard,WaghwaniHitesh Kumar,SelivanovitchEkaterina,PayS Louise,AveraJohn,YunEJun,SandovalRuben M,MolitorisBruce A,ZollmanAmy,DouglasTrevor,HatoTak
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摘要

Nature exploits cage-like proteins for a variety of biological purposes, from molecular packaging and cargo delivery to catalysis. These cage-like proteins are of immense importance in nanomedicine due to their propensity to self-assemble from simple identical building blocks to highly ordered architecture and the design flexibility afforded by protein engineering. However, delivery of protein nanocages to the renal tubules remains a major challenge because of the glomerular filtration barrier, which effectively excludes conventional size nanocages. Here, we show that DNA-binding protein from starved cells (Dps) - the extremely small archaeal antioxidant nanocage - is able to cross the glomerular filtra... More

关键词

Diagnostic imaging,Drug therapy,Nanotechnology,Nephro