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Interaction of the anticancer p28 peptide with p53-DBD as studied by fluorescence， FRET， docking and MD simulations.

Biochim Biophys Acta Gen Subj. 2019; 
BizzarriAnna Rita，MoscettiIlaria，CannistraroSalva
Products/Services Used Details Operation
Bacterial Expression System 4 kDa) was purchased from GenScript (Piscataway, NJ, USA) by using the BacPower™ Guaranteed Bacterial Protein Expression Service.... The p28 peptide (LSTAADMQGVVTDGMASGLDKDYLKPDD, 2914 Da), with the addition of a cysteine residue at the N-terminal (hereafter p28), was synthesised and verified by MS and HPLC (93% purity) by GenScript (Piscataway, NJ, USA). Get A Quote

摘要

The p28 peptide， derived from the blue copper protein Azurin， exerts an anticancer action due to interaction with the tumor suppressor p53， likely interfering with its down-regulators. Knowledge of both the kinetics and topological details of the interaction， could greatly help to understand the peptide anticancer mechanism.

关键词

Anticancer peptides，Computational docking，FRET，Fluorescence
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