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A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice.

Vaccine. 2019; 
WasanEllen K,SyedaJaweria,StromStacy,CawthrayJacqueline,HancockRobert E,WasanKishor M,GerdtsVo
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Biochemicals IDR- 1002 (VQRWLIVWRIRK) [29] was obtained from Genscript. Get A Quote

摘要

We previously developed an highly efficacious combination adjuvant comprised of innate defense regulator (IDR)-1002 peptide, poly(I:C) and polyphosphazene (TriAdj). Here we aimed to design and test the in vivo efficacy of a mucoadhesive nasal formulation of this adjuvant. To determine the physical properties of the formulation, the effect of addition of each individual component was characterised by gel electrophoresis and fluorescence quenching using rhodamine-poly(I:C). Cationic liposomes comprised of didodecyl dimethylammonium bromide (DDAB), dioleoyl phosphatidylethanolamine (DOPE) (50:50 or 75:25?mol:mol) and DDAB, L-α-phosphatidylcholine (egg PC) and DOPE (40:50:10?mol:mol:mol) were prepared by t... More

关键词

Adjuvant,Intranasal delivery,Liposomes,Nanoparticles,Self-assembled systems,Vac