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Harnessing high density lipoproteins to block transforming growth factor beta and to inhibit the growth of liver tumor metastases.

PLoS ONE. 2014; 
Medina-Echeverz José,Fioravanti Jessica,Díaz-Valdés Nancy,Frank Kathrin,Aranda Fernando,Gomar Celia,Ardaiz Nuria,Dotor Javier,Umansky Viktor,Prieto Jesús,Berraondo P
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Recombinant Antibody Services Recombinant ApoLin- kerP144 was produced and purified by Genscript (Piscataway, NJ, USA). Get A Quote

摘要

Transforming growth factor β (TGF-β) is a powerful promoter of cancer progression and a key target for antitumor therapy. As cancer cells exhibit active cholesterol metabolism, high density lipoproteins (HDLs) appear as an attractive delivery system for anticancer TGFβ-inhibitory molecules. We constructed a plasmid encoding a potent TGF-β-blocking peptide (P144) linked to apolipoprotein A-I (ApoA-I) through a flexible linker (pApoLinkerP144). The ApoLinkerP144 sequence was then incorporated into a hepatotropic adeno-associated vector (AAVApoLinkerP144). The aim was to induce hepatocytes to produce HDLs containing a modified ApoA-I capable of blocking TGF-β. We observed that transduction of the murine liv... More

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