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Sonic hedgehog secreted by neurons regulates angiopoietin expression in neighboring fibroblasts.

Int. J. Mol. Med.. 2014; 
Kim Woo Jean,Lee Sae-Won,Kim Kyu
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Recombinant Antibody Services Mouse recombinant Shh (mrShh) was purchased from GenScript (Piscataway, NJ, USA; Cat. Get A Quote

摘要

Lately, the importance of the communication between different cell types and the understanding of the cell communication pathway has been emphasized, as it may provide a novel therapeutic strategy for the regeneration of damaged tissue. In the present study, we suggest that sonic hedgehog (Shh) is a mediator of cell communication between neurons and fibroblasts. Recombinant Shh (rShh) affected the expression of the angiogenic factors, angiopoietin (Ang)-1 and Ang-2, in fibroblasts, but not in neurons or neural progenitor cells (NPCs). The expression of the Shh downstream transcription factor, Gli1, was markedly increased in neurons and NPCs, indicating that neurons and NPCs responded to rShh. ... More

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