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Treatment with a fusion protein of the extracellular domains of NKG2D to IL-15 retards colon cancer growth in mice.

J. Immunother.. 2014; 
Xia Yan,Chen Bei,Shao Xiaoqing,Xiao Weiming,Qian Li,Ding Yanbing,Ji Mingchun,Gong Wei
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Recombinant Antibody Services Before use, LPS was removed from the recombinant protein samples on a polymyxin B-modified resin column from Genscript (Nanjing, China), and the endotoxin concentration of each sample was checked and shown to be <0. Get A Quote

摘要

Tumor-targeted cytokines are a new class of pharmaceutical anticancer agents often considered superior to the corresponding unconjugated cytokines for therapeutic purposes. We generated a new fusion protein, dsNKG2D-IL-15, in which double NKG2D extracellular domains were fused to IL-15, in Escherichia coli. This fusion protein promoted the activation, proliferation, and cytotoxicity of NK cells, and bound to NKG2D ligand-positive tumor cells. These tumor cells were also more susceptible to NK-cell attack when decorated with dsNKG2D-IL-15. The administration of mouse dsNKG2D-IL-15 protein in vivo significantly retarded the growth of transplanted colon cancers and prolonged the survival of tumor-beari... More

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