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Discovery of a novel long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth.

Mol. Cancer. 2019;

TaHuy Q，WhitworthHilary，YinYi，ConawayMark，FriersonHenry F，CampbellMoray J，RajGanesh V，GioeliDa

Products/Services Used	Details	Operation
ORF cDNA Clones/MolecularCloud	According to the GenScript Codon Bias tool, the two short ORFs have low codon adaptation indices (CAI) (< 0.8), suggesting poor expression.	Get A Quote

摘要

Virtually all patients with metastatic prostate cancer (PCa) will relapse and develop lethal castration-resistant prostate cancer (CRPC). Long noncoding RNAs (lncRNAs) are emerging as critical regulatory elements of many cellular biological processes， and may serve as therapeutic targets for combating PCa progression. Here， we have discovered in a high-throughput RNAi screen a novel lncRNA in PCa， and assessed the oncogenic effects of this lncRNA.