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CHK2-FOXK axis promotes transcriptional control of autophagy programs.

SCIENCE ADVANCE. 2020; 
Chen Y,, Wu J,, Liang G, Geng G, Zhao F, Yin P, Nowsheen S, Wu C,, Li Y,, Li L,, Kim W, Zhou Q, Huang J, Liu J, Zhang C, Guo G, Deng M, Tu X, Gao X, Liu Z,, Chen Y,, Lou Z, Luo K,, Yuan J,.
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Monoclonal Antibody Services Anti–phospho-FOXK (p-S130-FOXK1 and p-S61-FOXK2) antibody was generated by GenScript. Get A Quote

摘要

Autophagy is an evolutionarily conserved catabolic process, which plays a vital role in removing misfolded proteins and clearing damaged organelles to maintain internal environment homeostasis. Here, we uncovered the checkpoint kinase 2 (CHK2)-FOXK (FOXK1 and FOXK2) axis playing an important role in DNA damage-mediated autophagy at the transcriptional regulation layer. Mechanistically, following DNA damage, CHK2 phosphorylates FOXK and creates a 14-3-3γ binding site, which, in turn, traps FOXK proteins in the cytoplasm. Because FOXK functions as the transcription suppressor of ATGs, DNA damage-mediated FOXKs' cytoplasmic trapping induces autophagy. In addition, we found that a cancer-derived FOXK mutation indu... More

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