| Products/Services Used | Details | Operation |
|---|---|---|
| Catalog Antibody | … 25 Quantitative reverse transcription-PCR (qRT-PCR) Primers were all designed by online software (wwwidtdnacom) and purchased from GenScript The sequences for these primers are described previously (Fu et al, 2017, Yuan et al, 2016, Wang et al, 2019) … | Get A Quote |
Colon cancer is one of the most common malignancies in the world; there is no effective therapeutic treatment after surgery. Our previous studies indicate that RNA helicase DHX33 plays a critical role in cell proliferation and cell growth. Here in this study, DHX33 is found to be highly expressed in colon cancer tissues and colon cancer cell lines. Knockdown of DHX33 significantly decreased cell proliferation and triggered apoptosis. Mechanistically, DHX33 was found to transcriptionally control multiple critical genes involved in cell cycle, apoptosis and migration. DHX33 deficiency caused decreased tumor growth for colon cancer cells in a xenograft model in vivo. With Wnt/β-cateninactivator and inhibitors, we... More
