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Human polyomavirus 7 (HPyV7)-associated dermatoses: novel molecular mechanism driven by viral activation of 4E-BP1 and MEK-ERK-cJun.

Int J Dermatol. 2019; 
Wu JH,, Narayanan D,, Simonette RA, Rady PL, Tyring SK.
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Monoclonal Antibody Services These findings suggest requirement of sT was confirmed by immunoblotting with a mouse monoclonal antibody (Genscript Inc; clone: 6H2G7) directed against aa 84– 193 of HPyV7 sT.... Proteins were then subjected to SDS-PAGE (4–12% polyacrylamide Bis-Tris gel, Novex) and immunoblotting with anti-HPyV7 sT monoclonal antibody (Genscript Inc. Get A Quote

摘要

A number of pruritic skin conditions arising in immunocompromised patients are associated with viral infection. Recently, human polyomavirus 7 (HPyV7) has been implicated in the pathogenesis of eruptive pruritic parakeratotic and dyskeratotic dermatoses with distinct "peacock plumage" histology. While expression of HPyV7 viral protein, namely small tumor (sT) antigen, is prominent within lesional tissue, the functional role of HPyV7 in cutaneous pathobiology is not yet known. In this study, we demonstrate a novel role for HPyV7 sT antigen in pathways important for the maintenance of keratinocyte structure and function. In particular, HPyV7 sT was found to dysregulate protein phosphatase 2A through physical inte... More

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