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Lack of evidence for a liver or intestinal miRNA regulation involved in the hypertriglyceridemic effect of APOC3 3'UTR variant SstI.

Atherosclerosis. 2016; 
Dancer M, Caussy C, Di Filippo M, Moulin P, Marçais C, Charrière S.
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Mutagenesis Services Site-directed mutagenesis was performed to introduce c*40G (S2) and/or c*71G (B2) alleles in pEZX-S1B1, creating variants vectors: pEZX-S1B2, pEZX-S2B1, pEZX-S2B2 (GenScript, Piscataway, USA). Get A Quote

摘要

APOC3 is a major regulator of triglycerides metabolism. Several APOC3 variants are associated with hypertriglyceridemia (HTG). Our aim was to establish the potential regulation of APOC3 3'UTR variants associated with HTG by liver or intestinal miRNAs.,We sequenced APOC3 3'UTR in 100 type 2 diabetic (TD2) patients with severe HTG (TG > 15 mmol/L) (HTG group) compared to 100 normotriglyceridemic patients (NTG group). We performed in silico studies to identify potential loss of miRNA binding induced by APOC3 3'UTR variants. We also performed in vitro studies to test the functionality of miRNA/APOC3 variants interactions: APOC3 3'UTR plasmids coupled with a firefly luciferase reporter were transfected in HepG2,... More

关键词

APOC3; Lipids; Polymorphism; SNP; Triglycerides; miR; microRNA