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A Fragment of Apolipoprotein E4 Leads to the Downregulation of a CXorf56 Homologue, a Novel ER-Associated Protein, and Activation of BV2 Microglial Cells.

Oxid Med Cell Longev. 2019; 
Pollock TB, Mack JM, Day RJ, Isho NF, Brown RJ, Oxford AE, Morrison BE, Hayden EJ, Rohn TT.
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Biochemicals … (Cambridge, MA). MitoTracker Deep Red FM was purchased from Thermo Fisher Scientific (Rockford, IL). Construction and purification of the amino-terminal fragment 1-151 for apoE4 (nApoE4 1-151 ) were contracted out to GenScript (Piscataway, NJ) … Get A Quote

摘要

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer's disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fragment of apoE4 (nApoE41-151) localizes within the nucleus of microglia in the human AD brain, suggesting a potential role in gene expression. In the present study, we investigated this possibility utilizing BV2 microglia cells treated exogenously with nApoE41-151. The results indicated that nApoE41-151 leads to morphological activation of microglia cells through, at least in part, the downregulation of a novel ER-associat... More

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