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Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter.

IBRO Rep. 2019; 
Wykes AD,, Ma S,, Bathgate RAD,,, Gundlach AL,.
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Biochemicals … 1999; Ma et al. 2000) and human (Chang et al. 1998), resulting in selection of an 880 bp TrkA promoter region for characterisation (synthesised by GenScript (Piscataway, NJ, USA)). Data presented in Supplementary Fig. 1 … Get A Quote

摘要

Modern neuroscience utilizes transgenic techniques extensively to study the activity and function of brain neural networks. A key feature of this approach is its compatibility with molecular methods for selective transgene expression in neuronal circuits of interest. Until now, such targeted transgenic approaches have not been applied to the extensive circuitry involving the neuropeptide, relaxin-3. Pharmacological and gene knock-out studies have revealed relaxin-3 signalling modulates interrelated behaviours and cognitive processes, including stress and anxiety, food and alcohol consumption, and spatial and social memory, highlighting the potential of this system as a therapeutic target. In the present study, ... More

关键词

Adeno-associated viral (AAV) vector; Cell-type specific promoter; Medial septum; Nucleus incertus; Relaxin-3; Tropomyosin receptor kinase A (TrkA)