至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Tanshinone IIA Ameliorates CNS Autoimmunity by Promoting the Differentiation of Regulatory T Cells.

Neurotherapeutics. 2019; 
Gong Y, Liu YC, Ding XL, Fu Y, Cui LJ,, Yan YP,.
Products/Services Used Details Operation
Custom DNA/RNA Oligos … Carboxyfluorescein diacetate succinimidyl ester (CFSE) proliferation dye was from eBioscience (Santa Clara, CA). Myelin oligodendrocyte glycoprotein (MOG) 3 5 – 5 5 peptide (MEVGWYRSPFSRVVHLYRNGK, purity ≥ 98%) was pur- chased from GenScript (Nanjing, China) … Get A Quote

摘要

Tanshinone IIA (TSA), an important natural lipophilic diterpene compound from the traditional Chinese herb Salvia miltiorrhiza Bunge, has long been widely used for the prevention and treatment of various diseases because of its anti-inflammatory activities; however, the anti-inflammatory mechanism remains unknown. In the present work, we examined the effects of TSA on experimental autoimmune encephalomyelitis (EAE), a model of autoreactive T/B cell-mediated central nervous system (CNS) autoimmunity. The data showed that TSA significantly attenuates the severity of EAE when administered at the pre-onset and peak of clinical disease. In vivo, the protective effects of TSA on EAE mice are correlated with diminishe... More

关键词

Tanshinone IIA (TSA); Treg cell; experimental autoimmune encephalomyelitis (EAE); multiple sclerosis (MS); transforming growth factor β1 (TGF-β1)