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Improvement of memory deficits in the rat model of Alzheimer's disease by erythropoietin-loaded solid lipid nanoparticles.

Neurobiol Learn Mem. 2019; 
Dara T, Vatanara A, Sharifzadeh M, Khani S, Vakilinezhad MA, Vakhshiteh F, Nabi Meybodi M, Sadegh Malvajerd S, Hassani S, Mosaddegh MH.
Products/Services Used Details Operation
Biochemicals … AD 2 Materials and methods 21 Materials Erythropoietin (EPO) was kindly donated by the Pasteur Institute of Iran Beta amyloid Beta amyloid 1-42 (Aβ) was purchased from the GenScript (Piscataway, USA) Polysorbate80 … Get A Quote

摘要

Erythropoietin (EPO), a hematopoietic factor, is one of the promising neuroprotective candidates in neurodegenerative disorders such as Alzheimer's disease (AD). Due to the high molecular weight, hydrophilicity and rapid clearance from circulation, EPO could not completely pass the blood-brain barrier in the case of systemic administration. To overcome this limitation, EPO-loaded Solid Lipid Nanoparticle (EPO-SLN) was developed in this study using a double emulsion solvent evaporation method (W1/O/W2). Glycerin monostearate (GMS), span®80/span®60, Dichloromethane (DCM) and tween®80 were chosen as lipid, internal phase surfactants, solvent, and external aqueous phase surfactant, respectively. After physicoche... More

关键词

Alzheimer’s disease; Beta amyloid; Erythropoietin; Morris water maze; Oxidative stress; Solid lipid nanoparticle