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Substance P-loaded electrospun small intestinal submucosa/poly(ε-caprolactone)-ran-poly(l-lactide) sheet to facilitate wound healing through MSC recruitment.

J Mater Chem B. 2019; 
Kim MJ, Ji YB, Seo JY, Park SH, Kim JH, Min BH, Kim MS.
Products/Services Used Details Operation
Biochemicals … Seoul, Korea) Indocyanine green powder (ICG) and protamine sulfate were purchased from TCI Chemicals (Chuo-ku, Tokyo, Japan) Substance P (SP; M w = 13476 Da) was purchased from Genscript (NJ, USA) Low-glucose … Get A Quote

摘要

In this work, we prepared an electrospun small intestinal submucosa/poly(ε-caprolactone)-ran-poly(l-lactide) (SIS/PCLA) sheet onto which substance P (SP) was loaded, and this was employed as a cell-free scaffold for wound healing through the mobilization of human mesenchymal stem cells (hMSCs). SP release from the SP-loaded scaffold was 42% at 12 h and 51% at 24 h due to an initial burst of SP, but after 1 day, it exhibited a linear release profile and was released at a sustained rate for 21 days. The SP-loaded SIS/PCLA sheet exhibited higher in vitro and in vivo hMSC migration than did the PCLA and SIS/PCLA sheets. Large hMSCs injected into the tail vein of mice models migrated towards the wound to a greater ... More

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