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Chitosan Nanoparticles Strengthen Vγ9Vδ2 T-Cell Cytotoxicity Through Upregulation Of Killing Molecules And Cytoskeleton Polarization.

Int J Nanomedicine. 2019; 
Lin L,, He J, Li J, Xu Y, Li J, Wu Y,.
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Nucleic Acid Purification & Analysis … Then, 200 μL of 50 μg/mL CSNPs solution was added to the ToxinSensor TM Single Test Kit (GenScript, sensitivity is 006 EU/mL) and incubated at 37°C for 1 hr to check whether a gel had formed or not Human PBMCs Isolation And Vγ9Vδ2 T Cell Culture … Get A Quote

摘要

During the past few years, immune cell therapy for malignant cancer has benefited a considerable amount of patients worldwide. As one of several promising candidates for immunotherapy, Vγ9Vδ2 γδ T cells have many unique biological advantages, such as non-MHC restriction and have been noted as the earliest source of IFN-γ. However, potentiating anti-tumor functions of γδ T cells has become of particular interest to researchers studying γδ T cell applications.,In this study, we proposed a nanotechnology-based methodology for strengthening γδ T cell functions.,As a type of reliable, biocompatible material, chitosan nanoparticles (CSNPs) were used to enhance anti-tumor immunity of γδ T cells.,First, we... More

关键词

Vγ9Vδ2 γδ T cell; anti-tumor activity; chitosan nanoparticles; cytotoxicity